ASSESSMENT OF THE PHYSIOLOGICAL FACTORS ON THE REGROWING TUMOR AFTER RADIATION THERAPY

从肿瘤局部控制和患者生活质量的角度来看，放射治疗变得越来越重要。然而，放射抵抗再生长肿瘤的生物学背景，特别是照射床的生理因素一直是未知的。在这项研究中，在小鼠肿瘤模型中，肿瘤床的生理因素已经使用P-31，H-2 NMR光谱和p02进行了研究。在肿瘤床中已经注意到低能量状态、缓慢的ATP合成、低pH和低p02。对照组瘤床内血管密度低，微血管增多，血管迂曲。总之，从生理因素分析，肿瘤床的低能量和低营养状态可能对再生长肿瘤产生早期影响，但局部控制与生理因素对放射抗性再生长肿瘤的关系还需要进一步研究。

Radiation therapy is becoming important from the point of view of local control on tumor and quality of life on patients. However, the biological background of radio-resistant regrowing tumor, especially physiological factors of irradiated bed is ever unknown. In this study, physiological factors on tumor bed in mouse tumor model have been investigated using P-31, H-2 NMR spectroscopy and p02. Low energy status, slow ATP synthesis, low pH and low p02 have been noted in tumor bed. In parallel, there are low density blood vessels in tumor bed and a large number of micro vessels, tortuous vessels have been shown in non-irradiated control group. In conclusion, low enegy status and low nutrition status on tumor bed may give an early effect to regrowing tumor by analysis of physiological factors but further investigation will be needed to elucidate the relationship between local control and physiological factors on radio-resistant regrowing tumor.