Regulatory mechanism of dopamine metabolism in rat brain.

1.本文观察了氟哌啶醇癸酸酯（Haloperidol decanoate，HVA）对大鼠多巴胺（DA）及其代谢产物（DOPAC和HVA）的影响。结果表明，第1天HVA的初始增加早在第3天就已显着减弱，并在第11天进一步减弱，几乎平行地出现在额叶皮质、尾壳核和杏仁核中。2. (1)（2）用在体微透析法观察甲基苯丙胺急性给药对损毁大鼠左杏仁核DA释放的影响。结果表明：（1）与对照组相比，术后第28天的唯一变化是外侧杏仁核内DA含量增加。(2)损毁组大鼠左侧杏仁核DA释放量显著高于对照组。这些结果表明，内嗅皮层损伤大鼠可能是一个有用的动物模型，以研究DA过度活动的精神分裂症。

1.Changes in concentrations of dopamine (DA) and its metabolites (DOPAC and HVA) follwing haloperidol decanoate administration in rat were investigated. The results showed that the initial increase in HVA on day 1 had significantly attenuated as early as day 3 and diminished further on day 11 almost in parallel in the frontal cortex, caudate-putamen, and amygdala.2.(1) Concentration of DA and its metabolites following the left entorhinal cortex lesion in rat brain were datermined and (2) The effects of acute administration of methamphetamine on DA release in the left amygdala in lesioned rats was measured by the in vivo microdialysis method. The results showed that (1) the only change on the 28th postoperative day was the increased concentration of DA in the lateral amygdala compared with the controls. (2) The DA release in the left amygdala in the lesioned rats was significantly higher than that in the controls. These results suggest that the entorhinal cortex lesioned rats may be useful for an animal model to study DA overactivity in schizophrenia.