Long-Term Follow-up Study of Patients with Persistent Sleep-Wake Rhythm Disorders and Social Maladjustment

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We investigated the response to treatment and long-term course of patients with persistent sleep-wake schedule disorders who had formly received intensive treatment. The investigation was carried out with mailed questionnaires and the use of their hospital records about current sleep conditions and social state. Ten adolescents (7 delayd sleep phase syndrome (DSPS) , 3 non-24-hour sleep-wake syndrome) and 14 adults with delayd sleep phase syndrome were subjects and the follow-ups were obtained from 1.2 to 11.2 years after the initial treatment.Improvement in the social adaptation level was greater than improvement in the illness severity level in both adolescents and adults. All the DSPS patients (21 cases ; 7 adolescents and 14 adults) showed significant improvement in both the social adaptation and the illness severity. A follow up of these patients with persistent sleep-wake rhythm disorders showed consistent improvement after intensive intervention. These findings suggest that a long-term follow-up is needed to judge the effect of the treatment and more cases should be studied to learn with factors influence the pathogenesis and the prognosis of these disorders.