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Long-Term Follow-up Study of Patients with Persistent Sleep-Wake Rhythm Disorders and Social Maladjustment

持续性睡眠-觉醒节律障碍和社会适应不良患者的长期随访研究

基本信息

批准号：
05670807
负责人：
OHTA Tatsuro
金额：
$ 1.34万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670807/
关键词：
Sleep-wake rhythm disorders delayd sleep phase Syndrome non-24-hour sleep-wake disorder Adolescent young adult social maladjustment prognosis treatment prevalence

项目摘要

We investigated the response to treatment and long-term course of patients with persistent sleep-wake schedule disorders who had formly received intensive treatment. The investigation was carried out with mailed questionnaires and the use of their hospital records about current sleep conditions and social state. Ten adolescents (7 delayd sleep phase syndrome (DSPS) , 3 non-24-hour sleep-wake syndrome) and 14 adults with delayd sleep phase syndrome were subjects and the follow-ups were obtained from 1.2 to 11.2 years after the initial treatment.Improvement in the social adaptation level was greater than improvement in the illness severity level in both adolescents and adults. All the DSPS patients (21 cases ; 7 adolescents and 14 adults) showed significant improvement in both the social adaptation and the illness severity. A follow up of these patients with persistent sleep-wake rhythm disorders showed consistent improvement after intensive intervention. These findings suggest that a long-term follow-up is needed to judge the effect of the treatment and more cases should be studied to learn with factors influence the pathogenesis and the prognosis of these disorders.

我们调查了持续性睡眠-觉醒时间表障碍患者的治疗反应和长期病程，这些患者以前接受过强化治疗。调查是通过邮寄问卷和使用他们的医院记录来进行的，这些记录是关于目前的睡眠状况和社会状态的。对10例青少年（7例睡眠时相延迟综合征（DSPS），3例非24小时睡眠-觉醒综合征）和14例成人睡眠时相延迟综合征患者进行治疗，随访时间为1.2 ~ 11.2年，青少年和成人的社会适应水平的改善大于疾病严重程度的改善。所有DSPS患者（21例，7例青少年和14例成人）在社会适应和疾病严重程度方面均表现出明显的改善。对这些持续性睡眠-觉醒节律紊乱患者的随访显示，强化干预后持续改善。这些结果表明，需要长期随访来判断治疗效果，并应研究更多的病例，以了解影响这些疾病的发病机制和预后的因素。