The regulation of gene expression for the genes associated with eosinophils.
The regulation of gene expression for the genes associated with eosinophils.
批准号:
05670927
负责人:
YAMAGUCHI Yuji
金额:
$1.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994
中文摘要
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英文摘要
The analysis of the regulation of gene expression for the genes associated with eosinophils were caried out.1.GATA-1 plays an important role in the eosinophil defferentiation of eosinophilic cell line, HL-60-C15 cells, and normal human bone marron cells.2.In the promoter for the gene encoding human eosinophil peroxidase, a number of positively and negatively acting elements were identified.3.The regulatory regions of Charcot-Leyden crystal protein were identified.
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Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., Ackerman, S.J.: "Expresion of mRNA for the GATA-binding proteins in human eosinophils and basophils : Potential role in gene transcription." Blood. 81. 3234-3241 (1993
Zon, L.I.、Yamaguchi, Y.、Yee, K.、Albee, E.A.、Kimura, A.、Bennett, J.C.、Orkin, S.H.、Ackerman, S.J.:“人嗜酸性粒细胞和嗜碱性粒细胞中 GATA 结合蛋白的 mRNA 表达
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作者:
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通讯作者:
Gomolin, H.I., Yamaguchi, Y., Palupillai, A.V., Dvorak, L.A., Ackerman, S.J., Tenen, D.G.: "Human eosinophil Charcot-Leyden crystal protein : Cloning and characterization of a lyso phospholipase gene promoter." Blood. 82. 1868-1874 (1993)
Gomolin, H.I.、Yamaguchi, Y.、Palupillai, A.V.、Dvorak, L.A.、Ackerman, S.J.、Tenen, D.G.:“人嗜酸性粒细胞 Charcot-Leyden 晶体蛋白:溶血磷脂酶基因启动子的克隆和表征。”
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作者:
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通讯作者:
Gomolin,H.I.: "Human eosinophil Charcot-Leyden crystal Protein:Cloning and characterization of a lysophospholipase gene promoter." Blood. 82. 1868-1874 (1993)
Gomolin,H.I.:“人嗜酸性粒细胞夏科-莱登晶体蛋白:溶血磷脂酶基因启动子的克隆和表征。”
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通讯作者:
Yamaguchi,Y.: "Functional characterization of the promoter for the gene encoding human eosinophil peroxidase." J.Biol.Chem.269. 19410-19419 (1994)
Yamaguchi,Y.:“编码人嗜酸性粒细胞过氧化物酶的基因启动子的功能特征。”
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作者:
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通讯作者:
Yuji Yamaguchi: "Functional Characterization of the Promoter for the Gene Encoding Human Eosinophil Peroxidase" J.Biol Chem.269. 19410-19419 (1994)
Yuji Yamaguchi:“编码人嗜酸性粒细胞过氧化物酶的基因启动子的功能特征”J.Biol Chem.269。
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批准号:08671244
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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负责人:YAMAGUCHI Yuji
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依托单位:
海外基金