Clinical and experimental studies on the liver cell damage under segmental cholestasis

1.研究了选择性胆汁淤积对大鼠肝脏线粒体能量传递系统的影响。结果表明，在长时间的节段性胆汁淤积过程中，尽管血清生化指标正常，非胆汁淤积性叶肥大，但非胆汁淤积叶的线粒体能量传递系统并未增强，而是明显受损。2.为明确胆道癌肝切除术后发生肝功能衰竭的危险因素，我们分析了118例晚期胆道癌患者行肝大部切除术后的临床表现。结果表明，术前肝内胆管炎是肝大部切除术患者最危险的因素之一。此外，选择性经皮肝穿胆管引流对减少肝大部切除术后并发症有重要作用。3.探讨胆道感染和引流对梗阻性黄疸时肝功能的影响。梗阻性黄疸合并胆管炎时，肝线粒体的磷酸化能力受到更严重的影响。在有感染的情况下，胆汁引流后磷酸化能力的恢复明显受到抑制。

1.We have examined the effects of selsctive cholestasis on the mitochondrial enargy transduring system inrat liver. It was indicated that the mitocondrial energy transducing system in thenon-cholestatic lobe was not enhanced, but is significantly impaired during prolonged segmental cholestasis, despite normal serum biochemical date and hyper trophy of non-cholestatic lobe.2.In order to define the risk factors for hepatic failur after liver resection for carcinoma of the biliary tract, wa have analyzed the cliical findings on 118p atients with advanced carcinoma of the biliary tract who underwent major hapatic resection, including bisegments and more. It was diclosedthat preperative intrahepatic srgmental cholangitis was one of the most risky factors in patients, undergoing major hapatic resection. Futhermore, selective percutaneous transhhepatic biliary drainage for the cholangitis playd an important role to reduce the complications after major hepatic resesction.3.The effects of billiary infection and the drainage on the functional changes in the liver under obstructive jaundice was studied. The phosphorylating ability of hepatic mitochondria was more seriously affected when the obstructive jaundice was complicated by cholangitis. The recovery of phosphorylating ability after biliary drainage was significantly restrained in the presence of infection.