Experimental study of etiology and therapeutics of spinal deformity

本实验采用日本白色家兔新品系--Lordoscoliotic兔（LSR），研究了在生长过程中自发发生胸椎前凸或脊柱前凸的过程、病理生理和治疗方法。1）组织病理学研究：对8-48周龄LSR的异常弯曲脊柱的椎体和椎间盘进行组织病理学检查。在8周龄时观察到的主要变化是髓核的平移和纤维环的伸展/压缩。12周龄时，椎体生长软骨发生变化，此后变化加剧，24周龄时，骨骺楔化，48周龄时，纤维环空泡化，骨赘形成。2）后部结构切除矫正脊柱畸形的实验研究：在8周龄时，第一组LSR在 关于我们 第二组切除椎旁肌，第三组切除椎旁肌、棘上韧带和棘间韧带。在此之后，有一种趋势，即在第二组中的畸形的进展在X线摄影上小于第一组。第二组与第三组之间无显著差异。3）激光髓核摘除术矫正脊柱畸形：我们开创了仅供动物使用的新型钕钇铝石榴石（Nd：YAG）激光探针，由23号针和裸石英纤维组成，试图矫正LSR的脊柱畸形，但无法获得有效的激光照射。因此，我们不得不放弃这项研究。4）激光髓核切除术用于破坏脊椎生长软骨：使用年龄为16 - 20周的LSR。已开发的Nd：YAG激光器由双腔针和裸石英光纤组成，用于破坏椎体生长软骨。我们正在寻找最佳的辐照条件。我们相信，进一步的研究将有助于脊柱侧凸的矫正。少

Using a new strain of Japanese white rabbits, the Lordoscoliotic rabbits (LSR), which spontaneously develop thoracic lordosis or lordoscoliosis during the growth, we studied the course, pathophysiology and treatment of spinal deformities.1)Histopathological study : The vertebral body and disc of the abnormally curved spine were histopathologically examined in LSR at 8-48 weeks of age. The major changes observed at 8 weeks of age were translation of the nucleus pulposus and extension/compression of the annulus fibrosus. At 12 week of age, changes of vertebral growth cartilage were found. Thereafter, these changes intensify and at 24 week of age, wedging of the epiphysis was observed and at 48 weeks of age, vacuolation of the annulus fibrosus and formation of osteophytes were seen.2)Experimental study of the resection of posterior elements for the correction of spinal deformity : At 8 weeks of age, first group of LSR were subperiosteally stripped of paravertebral muscles at the level of … More deformity, second group were resected of paravertebral muscles and third group were resected of paravertebral muscles, supraspinatous and interspinatous ligaments. After that, there is a tendency that the progression of the deformity in second group was raiographically lesser than in first group. There was no significant difference between in second and third group.3)Laser nucleotomy for correction of spinal deformity : We pioneered new Neodymium-yttrium-aluminum-garnet (Nd : YAG) laser probe for animal use only which was consisted of 23 gauge needle and a bare quartz fiber, to try to correct the spinal deformity of LSR,but were not able to get effective laser irradiation. So that, we could not but relinquishing this study.4)Laser nucleotomy for destruction of vertebral growth cartilage : LSR whose ages ranged from 16 to 20 weeks have been used. Already developed Nd : YAG laser prove which is consist of double-lumen needle and a bare quartz fiber is utilized to destroy the vertebral growth cartilage. We are now seeking the best irradiating condition. Further investigation will, we believe, be able to pray a part in the correction of scoliosis. Less