Effects of cyclosporin, azathioprine and mizoribin on male reproduction in rats

本文观察了环孢素（Cs）、硫唑嘌呤（AZP）和咪唑立宾（MZR）对雄性大鼠生殖功能的影响，结果发现Cs、AZP和MZR给药6周后，附睾尾精子数呈剂量依赖性下降。注射Cs后，各Cs处理组的精子活动率均明显下降，并逐渐改善，而AZP和MZR处理组的精子活动率无明显变化，Cs、AZP和MZR处理6周后，睾丸曲细精管出现明显的剂量依赖性损伤，血清黄体生成素和卵泡刺激素水平在整个实验过程中保持不变。注射AZP和MZR后，血清睾酮水平立即显著降低，而Cs对血清睾酮水平无明显影响。结论：Cs、AZP和MZR对大鼠精原细胞有损伤作用，但只有Cs对附睾功能有损伤作用。

The effects of cyclosporin (Cs) , azathioprine (AZP) and mizoribin (MZR) on male reproduction in rats were examined.A dose-dependent decrease in the sperm count in the cauda epididymis was observed 6 weeks after Cs, AZP and MZR were administered. Sperm motility was significantly decreased in each Cs-treated group immediately after the injection of Cs and improved gradually, but was not changed in the AZP or MZR treated groups.Significant dose-dependent damage of the seminiferous tubules was demonstrated 6 weeks after administration of Cs, AZP and MZR.The serum levels of luteinizing hormone and follicle-stimulating hormone remained the same throughout the experiment. The serum level of testosterone was significantly low immediately after the injections of AZP and MZR,but was not changed by that of Cs.In conclusion, Cs, AZP and MZR injured the spermatogonia in rat, but only Cs injured the epididymal function as well.