Development of New Synthetic Methods based on Early Transition Metals

在我们正在进行的利用早期过渡金属锆、钒、铌等进行有机合成的研究项目中，我们已经开发了低价锆配合物、锆茂烯-丁烯配合物用于有机合成的巨大可能性。在过去的项目中，我们建立了一种用锆茂烯-丁烯配合物处理乙烯基糖衍生物制备光纯碳环的有效方法，并将其应用于生物活性分子的合成。我们还建立了基于锆新世与乙烯基环丙烷反应构建甾体侧链的方法，并研究了基于锆新世与烷氧甲基化甾体衍生物反应的短步构建甾体骨架的方法。

In our ongoing research project on organic syntheses using early transtition metals, zirconium, vanadium, niobium etc., we have exploited enormous possibilities of low valent zirconium complex, zirconocene-butene complex, for organic synthesis. During the past term of project we established an efficient method for the preparation of optically pure carbocycles by treating vinyl sugar derivatives with zirconocene-butene complex and an application to the synthesis of bioactive molecules. We also established the construction of steroidal side chain based on the reaction of zirconocene with vinylcyclopropane, and we have also studied a short-step construction of steroidal skeleton based on the reaction of zirconocene and alkoxymethylated stirene derivatives.