The role of mesocorticolimbic networks for emotional adaptation and well-being in the second half of life

中皮质边缘网络在后半生情绪适应和幸福中的作用

• 批准号: 433272253
• 负责人: Professorin Dr. Stefanie Brassen
• 金额: --
• 依托单位: Institut für Systemische Neurowissenschaften
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/433272253?language=en
• 关键词: role; mesocorticolimbic; networks; emotional; adaptation

Depression in later life is common and can have devastating consequences. On the other hand, findings on large data sets report an increase of emotional well-being from middle age onwards. Resilience research has now started to identify protective factors against mood disorders in middle and late life. Mesocorticolimbic networks seem to be crucial here given their involvement not only in late-life depression but also healthy emotional aging. For instance, mesocorticolimbic circuits modulate the processing of regretful experiences such as missed opportunities. Regret sensitivity and brooding are risk factors for depression, particularly in later life, while a reduced regret responsiveness has been related to successful aging. So far, it is unclear whether the “healthy” way to deal with regret indeed gradually changes across the lifespan, whether there are critical time-windows for such changes and how this is related to the functional and structural integrity of mesocorticolimbic neurocircuits. In our project, we can address these questions by making use of the unique opportunity to study a large-scale epidemiological dataset of 1000 participants between the age of 45 and 74 who undergo a multimodal imaging assessment and perform an established paradigm on missed opportunities and regret processing. In three work packages we investigate age-profiles in well-being, regret-responsiveness and mesocorticolimbic function/structure and their interactions. Findings will be incorporated to develop a prediction model of individual well-being across aging. The predictive value of this model can be directly tested in an independent data set. Our project can provide fundamentally new insights into behavioral and neural modulators of emotional health in the second half of life. Highlighting critical time-windows and risk-profiles may pave the way for individually tailored cognitive-behavioral prevention programs to modulate regulation of emotions.

晚年的抑郁症很常见，可能会产生毁灭性的后果。另一方面，对大型数据集的研究结果表明，从中年开始，情感幸福感有所增加。复原力研究现在已经开始确定中年和晚年情绪障碍的保护因素。中皮质边缘网络似乎是至关重要的，因为它们不仅参与晚年抑郁症，而且还参与健康的情绪老化。例如，中皮层边缘回路调节对遗憾经历（如错过机会）的处理。遗憾敏感性和沉思是抑郁症的危险因素，特别是在晚年，而减少遗憾反应与成功的老龄化有关。到目前为止，还不清楚处理遗憾的“健康”方式是否确实在整个生命周期中逐渐变化，这种变化是否存在关键的时间窗口，以及这与中皮质边缘神经回路的功能和结构完整性有何关系。在我们的项目中，我们可以通过利用独特的机会来研究1000名年龄在45岁至74岁之间的参与者的大规模流行病学数据集来解决这些问题，这些参与者接受了多模态成像评估，并对错过的机会和遗憾处理进行了既定的范例。在三个工作包中，我们研究了幸福感，后悔反应和中皮质边缘功能/结构及其相互作用的年龄概况。研究结果将被纳入开发一个预测模型的个人福祉在老龄化。该模型的预测值可以直接在独立的数据集中进行测试。我们的项目可以为下半生情绪健康的行为和神经调节器提供全新的见解。强调关键的时间窗口和风险概况可能为个性化定制的认知行为预防计划铺平道路，以调节情绪。