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Mass Survery System Formation of Breast Cancer Detection by Visual Lights and Conservation Surgery and Irradiation of Early Breast Cancer

可见光检测乳腺癌的大规模调查系统的形成以及早期乳腺癌的保存手术和照射

基本信息

批准号：
06454323
负责人：
KANEKO Masao
金额：
$ 4.61万
依托单位：
Hamamatsu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

It is very important to make a good breast cancer mass survey system in the early stage by means of visual lights. From the residents of 5705, mass survey and individual examination were performed to obtain secondary candidates of 88 with palpable mass or from the high risk group. Laser Transmission Photo-Scanning (LTPS) technique was invented and used in this study for 33 out of 88. X-ray mammography (XMG) and Ultrasonography (US) were also performed. US is selected to standardize the final tumor evaluation. Abnormal findings of LTPS were due to 1) isolated abnormal translucency area, 2) abnormal difference between the both breasts and 3) abnormal feature or inhomogeneity of the breast tissue. Sensitivity and specificity of LTPS for tumor detection were 50% and 83% respectively, as in the cases of XMG.LTPS is suitable for repeated precise examinations of the breasts by the advantage of no radiation hazard. US guided aspiration by biopsy cytology and core biopsy with XMG and its conputer-aid by Cytoguide were very useful for the final pathology.Conservation surgery and irradiation was carried out in 30 cases of relatively early stage breast cancer. During the follow up period of average 23 months, one local recurrence, two distant metastasis and opposite side breast cancer revealed rather good result with less side effect and complications. Most of the patients were satisfied with good quality of life. Further follow up is necessary. It concludes the importance of breast cancer mass survey system with image and pathology diagnosis, and good combination of conservation surgery and irradiation of early breast cancer.

利用可见光做好乳腺癌早期普查系统非常重要。从5705名居民中，通过普查和个体化检查，获得88名可触及肿块或高危人群的二级候选人。激光透射光扫描（LTPS）技术被发明并用于这项研究中的33 88。还进行了X线乳腺摄影（XMG）和超声检查（US）。选择US以标准化最终肿瘤评价。LTPS的异常表现是由于1）孤立的异常半透明区，2）两个乳房之间的异常差异和3）乳房组织的异常特征或不均匀性。LTPS对乳腺肿瘤检出的敏感性为50%，特异性为83%，与XMG相似，无辐射危害，适合于乳腺的重复精确检查。超声引导下穿刺细胞学检查、XMG针芯活检及Cytoguide计算机辅助下穿刺细胞学检查对最终病理诊断有重要意义。术后平均随访23个月，1例局部复发，2例远处转移及对侧乳腺癌，效果良好，不良反应及并发症少。大多数患者对生活质量满意。有必要采取进一步的后续行动。总结了乳腺癌普查系统结合影像学和病理学诊断的重要性，以及早期乳腺癌保乳手术与放疗的良好结合。