Vascular permeability and regional blood flow in malignant brain tumors

采用大鼠脑肿瘤模型，观察颈动脉内输注组胺、前列腺素I2和钙通道阻滞剂对肿瘤内血流的影响。通过氢清除法测量，颈动脉内输注这些物质选择性地增加了瘤内血流量。此外，颈动脉内输注组胺增加了大鼠脑肿瘤模型瘤内通透性，放射自显影检查。缓激肽对脑肿瘤通透性的影响与组胺相同，颈动脉内灌注缓激肽增加了不同分子大小的肿瘤通透性，从103到70000不等。此外，我们发现这种腔内输注方法增加了抗肿瘤药物的实际递送量，延长了大鼠脑肿瘤模型的生存时间。提示该方法可应用于脑肿瘤化疗。

We examined the effects of intracarotid infusion of histamine, prostagrandin I2, and calcium channel blocler on intratumoral blood flow using rat brain tumor model. Intracarotid infusion of these substances selectively increased intratumoral blood flow measured by hydrogen clearance methods. Moreover, intracarotid infusion of histamine increased the intratumoral permeabikity in rat brain tumor model, which was examined by autoradiography. Bradykinin also had a same effect on brain tumor permeanbility as histamine had, and intracarotid bradykinin infusion increased tumor permeability of various molecular size, which was from 103 to 70000. Furthermore, we found this intracaroitd infusion method increased actual antitumor drug delivery, and this method prolonged the survival time of rat brain tumor model. These results suggeted that this intracarotid infusion method can be applied for the brain tumor chemotherapy.