CD96 as checkpoint for the persistence of T cell responses in the central nervous system (A01)

CD96 作为中枢神经系统 T 细胞反应持续性的检查点 (A01)

• 批准号: 434443429
• 金额: --
• 依托单位: Neurologische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/434443429?language=en
• 关键词: CD96; checkpoint; persistence; cell; responses

Compartmentalized inflammatory processes within the CNS might be a driver of tissue damage in chronic stages of CNS autoimmunity. Tissue resident T cells constitute a sizeable population of immune cells in the chronically inflamed CNS. However, little is known about their functional integration into CNS tissue niches. Here, we have identified the co-inhibitory molecule CD96 to be expressed on a subset of CNS resident conventional and regulatory T cells. Using genetic tools, we aim to investigate the interaction of CD96 with its CNS-expressed ligands and interrogate its function as a checkpoint to control perpetuation vs resolution of CNS resident T cell populations in the chronically inflamed CNS.

CNS内的区室化炎症过程可能是CNS自身免疫慢性阶段组织损伤的驱动因素。组织驻留T细胞构成慢性炎症CNS中相当大的免疫细胞群体。然而，很少有人知道他们的功能整合到中枢神经系统组织龛。在这里，我们已经确定了共抑制分子CD96上表达的中枢神经系统居民的常规和调节性T细胞的子集。利用遗传学工具，我们的目标是研究CD96与其CNS表达的配体的相互作用，并询问其作为检查点的功能，以控制慢性炎症CNS中CNS驻留T细胞群的永久化与消退。