感温磁性材料埋め込み加温法による気道内腫瘍のハイパーサーミア治療

热敏磁性材料植入加热法热疗气道肿瘤

• 批准号: 14657317
• 负责人: 小川 純一
• 金额: $ 2.05万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14657317/
• 关键词: ハイパーサーミア; 感温性磁性体; Helmholtz coil; 肺癌; 気道狭窄

背景:進行肺癌における気道内腫瘍浸潤、気道閉塞は呼吸困難を伴うため可及的早期の気道開大が必須である.現在行われているステント挿入やレーザー焼灼などの方法はいずれも重大な合併症の可能性を有し、また患者にとっても苦痛を伴うなど問題点が残っている.そこで今回、微小感温磁性体を内視鏡下に腫瘍内に注入、体外から励磁波をあてて発熱させるハイパーサーミア治療を考案し、本研究を計画した.方法:秋田大学工学資源学部との共同研究により、まず電磁誘導による磁性体の発熱試験を行った.市販の電磁調理器の誘導加熱用コイルを用い、磁束密度を測定しつつ各種金属片の温度上昇をサーマルカメラ(AVIO TVS-600)で記録し解析した.結果:高周波磁場(7.21mT,22.91kHz)では径0.7mmのロッド状磁性体で30秒間の誘導磁場により50度付近まで加熱できることが分かった。またこのような高周波磁場を実現するためのコイル形状を解析した結果、人体にも応用可能な形状のHelmholtz coil(半径10cm,巻数300)で有効磁束密度が得られることが解明された.現在、企業に外注し冷却装置も含め臨床応用を想定した試作機を作成中である.試作機完成後は、まずラットを用いたin vivo研究により生体内での局所加温の検証、腫瘍縮小効果、および正常組織の発熱も含め熱損傷についても充分な検討を加え、早期臨床応用を目標とする.

Background: it is necessary for lung cancer patients to undergo intra-arterial immersion and respiratory distress in the early stages within the reach of lung cancer. Now, we need to know that there is a possibility of major concomitant symptoms, such as pain, pain and pain. This time, the micro-temperature-sensitive magnets are injected into the interior of the camera, the excitation waves in vitro, the magnetic waves, the treatment cases, and the plan of this study. Methods: the Department of Engineering and Resources of Akita University worked together to study the electrical and magnetic properties of magnetic materials. The electrical and magnetic equipment of the market is used to determine the temperature and temperature of all kinds of metal sheets by using the magnetic beam density analyzer and the magnetic beam density analyzer (AVIO TVS-600). Results: the high-frequency magnetic field (7.21mT 22.91kHz) has a high-frequency magnetic field (7.21mT 22.91kHz). The radius of the 0.7mm magnetic field is 50 degrees above 50 degrees in 30 seconds. The results of the analysis of the shape of the high-frequency magnetic field, the results of the analysis of the shape of the high-cycle magnetic field, the results of the analysis of the shape, the results of the analysis of the shape of the high-cycle magnetic field, the results of the analysis of the shape, the results of the analysis of the shape of the high-cycle magnetic field, the results of the analysis of the shape of the high-cycle magnetic field, the results of the analysis of the shape, the results of the analysis of the shape, the results of the analysis of the shape of the human body. At present, the enterprise's external injection cooling device is used in the construction of the equipment in which the machine is used. After the completion of the test machine, please use the in vivo to study the heating temperature of the health department, the small fruit, the normal tissue temperature, the temperature and the temperature.