SPP 1365: The Regulatory and Functional Network of Ubiquitin Family Proteins

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Ubiquitin (Ub) has classically been associated with protein degradation via the 26S proteasome. However, in the past decade various non-proteolytic functions of Ub have been elucidated. Additionally, the discovery and investigation of Ub family proteins (UbF) such as SUMO, NEDD8, FAT10 or ISG15, the majority of which do not primarily function as signals for proteasomal degradation, have provided important new insights in our understanding of cellular key processes, such as signal transduction, DNA repair, transcriptional regulation or protein trafficking. The coordinated investigation of the regulatory and functional network of UbF proteins is the major aim of the Priority Programme. The participants will delineate the interplay and interconnection of UbF pathways as a novel regulatory principle for many important biological processes. The ultimate goal is to provide an integrated view of the UbF network, major aims are: