SPP 1365: The Regulatory and Functional Network of Ubiquitin Family Proteins

SPP 1365：泛素家族蛋白的调控和功能网络

• 批准号: 43455480
• 金额: --
• 依托单位: Institut für Experimentelle Innere Medizin
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/43455480?language=en
• 关键词: SPP; 1365; Regulatory; Functional; Network

Ubiquitin (Ub) has classically been associated with protein degradation via the 26S proteasome. However, in the past decade various non-proteolytic functions of Ub have been elucidated. Additionally, the discovery and investigation of Ub family proteins (UbF) such as SUMO, NEDD8, FAT10 or ISG15, the majority of which do not primarily function as signals for proteasomal degradation, have provided important new insights in our understanding of cellular key processes, such as signal transduction, DNA repair, transcriptional regulation or protein trafficking. The coordinated investigation of the regulatory and functional network of UbF proteins is the major aim of the Priority Programme. The participants will delineate the interplay and interconnection of UbF pathways as a novel regulatory principle for many important biological processes. The ultimate goal is to provide an integrated view of the UbF network, major aims are:

泛素（Ub）通常与通过26S蛋白酶体的蛋白质降解相关。然而，在过去的十年中，各种非蛋白水解功能的Ub已被阐明。此外，Ub家族蛋白（UbF）的发现和研究，如SUMO，NEDD8，FAT10或ISG15，其中大多数并不主要作为蛋白酶体降解的信号，为我们理解细胞的关键过程，如信号转导，DNA修复，转录调控或蛋白质运输提供了重要的新见解。UbF蛋白的调控和功能网络的协调调查是优先计划的主要目标。参与者将描述UbF途径的相互作用和相互联系，作为许多重要生物过程的新的调节原则。最终目标是提供UbF网络的综合视图，主要目标是：