SPP 1365: The Regulatory and Functional Network of Ubiquitin Family Proteins

泛素（Ub）通常通过26S蛋白酶体与蛋白质降解有关。然而，在过去的十年中，Ub的各种非蛋白水解功能已经被阐明。此外，Ub家族蛋白（UbF）如SUMO、NEDD8、FAT10或ISG15的发现和研究为我们理解细胞关键过程（如信号转导、DNA修复、转录调控或蛋白质运输）提供了重要的新见解，其中大多数不主要作为蛋白酶体降解信号。对UbF蛋白的调控和功能网络的协调研究是优先计划的主要目标。参与者将描述UbF通路的相互作用和互连，作为许多重要生物过程的新调控原则。最终目标是提供UbF网络的综合视图，主要目标是：

Ubiquitin (Ub) has classically been associated with protein degradation via the 26S proteasome. However, in the past decade various non-proteolytic functions of Ub have been elucidated. Additionally, the discovery and investigation of Ub family proteins (UbF) such as SUMO, NEDD8, FAT10 or ISG15, the majority of which do not primarily function as signals for proteasomal degradation, have provided important new insights in our understanding of cellular key processes, such as signal transduction, DNA repair, transcriptional regulation or protein trafficking. The coordinated investigation of the regulatory and functional network of UbF proteins is the major aim of the Priority Programme. The participants will delineate the interplay and interconnection of UbF pathways as a novel regulatory principle for many important biological processes. The ultimate goal is to provide an integrated view of the UbF network, major aims are: