Regulation of peptide hormones in carcinogenesis of the gastrointestinal tract

肽类激素在胃肠道癌变中的调控

• 批准号: 60480151
• 负责人: TAHARA Eiichi
• 金额: $ 0.51万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480151/
• 关键词: M N N G; Rat stomach carcinogenesis; Gastrin; Serotonin; CAMP依存性蛋白質リン酸化酵素; Ha-rasP21

A study of the effects of gastrin(pentagastrin, 300ug/kg twice daily, s.c. for 4 weeks) on gastric mucosal cyclic-adenosine 3':5'-monophosphate-dependent protein kinase activity in rat stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG, 50ug/ml for 32 weeks) showed that type 1 cAMP-depent protein kinase can play an important role in the enhanced effect of gastrin on rat stomach carcinogenesis induced by MNNG.2. A study of the effects of serotonin (8mg/kg, twice/day, s.c. for 20 days) on rat stomach carcinogenesis induced by MNNG, 50ug/ml or 80ug/ml for 32 weeks) showed that serotonin enhanced rat stomach carcinogenesis induced by MNNG, of which some parts may have relation to Ha-ras oncogene expression.

一项研究胃蛋白的影响（五核酸戊糖，每天两次两次/千克，s.c。，持续4周）对胃粘膜环状腺苷3'：5'-单磷酸蛋白依赖性蛋白激酶在大鼠胃癌中的作用在N-methyl-N'-N'-N'-N'N'-硝基n-硝基糖素（32周）中诱导的大鼠胃癌变（32个周四）营地depepent蛋白激酶可以在胃蛋白增强对MNNG.2诱导的大鼠胃癌发生的影响中发挥重要作用。一项研究5-羟色胺（8mg/kg，两次/天，s.c。）对MNNG诱导的大鼠胃癌发生的影响，50ug/ml或80ug/ml 32周）表明5-羟色胺增强了大鼠胃癌的作用，由MNNG诱导的某些部分，其中一些部分与Ha-Ras ancogene相关。

项目成果

Wataru Yasui;Hiromichi Sumiyoshi;Atsushi Ochiai;Mikimasa Yamahara;Eiichi Tahara: Cancer Research. 45. 1565-1568 (1985)

安井涉；住吉弘道；落合敦；山原干正；田原荣一：癌症研究。

Wataru Yasui;Hiromichi Sumiyoshi;Jotaro Hata;Kohichi Mandai;Eiichi Tahara: Journal of Cancer Research Clinical Oncology. 111. 87-92 (1986)

安井涉；住吉弘道；畑承太郎；万代浩一；田原荣一：癌症研究临床肿瘤学杂志。

Wataru Yasui;Eiichi Tahara: Cancer Research. 45. 4763-4767 (1985)

安井涉；田原英一：癌症研究。

i TaharaWataru Yasui;Hiromich Sumiyoshi;Tetsuro Yamamoto;Noriko Oda;Takashi Kameda;Takeo Tanaka;Eiich: Acta Pathol.Jpn.

i 田原安井涉；住吉博米奇；山本哲朗；织田纪子；龟田崇；田中武夫；Eiich：Acta Pathol.Jpn。

Wataru Yasui, Hiromichi Sumiyoshi, Jotaro Hata, Kohichi Mandai, and Eiichi Tahara: "Gut Endocrine Cells in Rat Stomach Carcinoma Induced by N-Methyl-N'-Nitro-N-Nitrosoguanidine" Journal of Cancer Research Clinical Oncology. 111. 87-92 (1986)

Wataru Yasui、Hiromichi Sumiyoshi、Jotaro Hata、Kohichi Mandai 和 Eiichi Tahara：“N-甲基-N-硝基-N-亚硝基胍诱导的大鼠胃癌中的肠道内分泌细胞”癌症研究临床肿瘤学杂志。