The target of genetic influence and participation of endorphin in chemical control of breathing.

遗传影响和内啡肽参与呼吸化学控制的目标。

• 批准号: 60480215
• 负责人: KAWAKAMI Yoshikazu
• 金额: $ 4.22万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480215/
• 关键词: control of breathing; ventilatory responses to hypoxia and hypercapnia; withdrawal test; peripheral chemoreceptor; naloxone; 双生児

To clarify whether genetic influence acts chiefly upon peripheral chemoreceptor function or that of medullary respiratory center, we studied withdrawal test in healthy adult twins [9 pairs of monozygotic twins (MZ) and 7 pairs of dizygotic twins (DZ)]. Further, we measured ventilatory response to hypercapnic progressive hypoxia either after normal saline or naloxone infusion to study whether naloxone affect chemosensitivity in coexistence of hypoxia and hypercapnia in healthy adults. A ventilatory index which represented hypoxic stimulation and peripheral <CO_2> - <O_2> interaction was genetically determined, whereas another index which represented hypoxic medullary depression and central <CO_2> - <O_2> interaction was influenced predominantly by environmental force. The ventilatory response to hypercapnic progressive hypoxia increased significantly after naloxone compared to normal saline in 16 subjects who were selected randomly from 16 different pairs of MZ and DZ. Within-pair variance for the change after naloxone in ventilatory response to hypercapnic progressive hypoxia was significantly smaller in MZ than DZ. These results suggest that genetic influence acts mainly upon peripheral chemoreceptor function and that endogenous opioids participate in chemical control of breathing in healthy adults. The funcion of endogenous opioids in control of breathing may involve genetically determined factors.

为了阐明遗传影响是否主要作用于外周化学感受器功能或延髓呼吸中枢功能，我们研究了健康成年双胞胎[9对单卵双胞胎（MZ）和7对双卵双胞胎（DZ）]的戒断试验。此外，我们测量了生理盐水或纳洛酮输注后对高碳酸进行性缺氧的缓解反应，以研究纳洛酮是否影响健康成人缺氧和高碳酸共存时的化疗敏感性。一个代表缺氧刺激和外周相互作用的解释指数<CO_2><O_2>是遗传决定的，而另一个代表缺氧延髓抑郁和中枢相互作用的指数<CO_2><O_2>主要受环境力的影响。从16对不同的MZ和DZ中随机选择16名受试者，与生理盐水相比，纳洛酮显著增加了对高碳酸进行性缺氧的缓解反应。纳洛酮对高碳酸进行性缺氧的缓解反应的变化在MZ中的对内方差显著小于DZ。这些结果表明，遗传影响主要作用于外周化学感受器功能，内源性阿片类物质参与健康成人呼吸的化学控制。内源性阿片类物质在呼吸控制中的作用可能与遗传因素有关。

项目成果

Yamamoto H: "Acute inhalation of cigarette smoke augments hypoxic chemosensitivity in humans." J Appl Physiol. 58. 717-723 (1985)

Yamamoto H：“急性吸入香烟烟雾会增加人类的缺氧化学敏感性。”

Kawakami Y: "Tracheal and lung dimensions in nonsmoking twins: morphological and functional studies." J Appl Physiol. 61. 495-499 (1986)

Kawakami Y：“不吸烟双胞胎的气管和肺部尺寸：形态学和功能研究。”

Yamamoto H,: J Appl Physiol. 58. 717-723 (1985)

山本 H，：J 应用生理学。

Kawakami Y: "Age-related variation of respiratory chemosensitivity in monozygotic twins." Am Rev Respir Dis. 132. 89-92 (1985)

Kawakami Y：“同卵双胞胎中呼吸系统化疗敏感性与年龄相关的变化。”

Kawakami Y,: J Appl Physiol. 61. 495-499 (1986)

川上 Y，：应用生理学杂志。