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Experimental and Clinical Studies on Transplantation of the Pancreas

胰腺移植的实验与临床研究

基本信息

批准号：
60480304
负责人：
TSUNODA Tsukasa
金额：
$ 2.75万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480304/
关键词：
Experimental transplantation of pancreatic islet Experimental segmental transplantation of pancreas Clinical autotransplantation of pancreatic islet Clinical segmental autograft of pancreas Segmental pancreas transplantation accompanied with splee

项目摘要

Experimental and clinical studies on pancreatic transplantation conducted at the 2nd Department of Surgery for the last 3 years were reported.A) Experimental studies1) Did transplanted pancreatic islets from chronic pancreatitis maintain normal glucose levels in dogs?Chronic pancreatitis was induced by injection of Freund's' complete adjuvant in 12 mongrel dogs. They were totally pancreatomized, and then all islet cells of the each dog were transplanted into the splenic pulp ofd the each dog respectively. The endocrine funcion was disturbed soon after islet transplantation in the dogs with severe fibrosis of the pancreas and the glucose level did not maintain normal.2) Was it necessary to drain the pancreatic ductal system in the dogs with segmental pancreas transplantation?Segmental pancreas transplantation with pancreaticojejunostomy or pancreatico-cystostomy after total pancreatectomy was done on 11 dogs. All dogs showed normal endocrine function for a long time without pancreatic f … More ibrosis. Although segmental pancreas transplantation with intraperitoneal drainage or duct occlusion using neoprene was done on 8 dogs, all dogs showed progressive disturbance of pancreatic function with severe fibroses .3) How to prevent throbosis of the splenic vein in the dogs with segmental pancreas transplantation?Segmental pancreas transplantation accompanied with spleen or splenic arteriovenous shunt without spleen was done an 15 dogs. In thase dogs. No Vasccelar thrcmbosis was seen. Although segfmental transplantation without spleen or arteriovenous shunt was done on 8 dogs, 50 of the dogs had vascular thrombosis and resulted in graft failure.B) Clinical studies.On the basis of those experimental results, pancreas islet autotransplantation and segmental pancreatic autograft were clinically done on 4 patients with chronic pancreatitis and 5 patients with pancreatoduodenal cancer. Four patients with chronic pancreatitis underwent subtotal distal pancreatectomy with islet transplantation and 3 with pancreatoduodenal cancer underwent total pancreatectomy with islet transplantation. One patient with carcinoma of the pancreas received segmental pancreatic autograft after total pancreatectomy with spleen and one patient without spleen.Postoperative pancreatic endocrine function was examined in 7 patients with islet transplantation. It was disturbed gradually in 5 patients and unchanged in 2 as compared with their preoperative function. In 2 patients with segmental pancreas autograft, one lost pancreatic autograft due to splenic venous thrombosis, and another is alive with normal pancreatic function after operation. Less

介绍了第二外科近3年来进行的胰腺移植的实验和临床研究。A）实验研究1）移植的慢性胰腺炎胰岛是否能维持犬正常的血糖水平？用弗氏完全佐剂诱发12只杂种犬慢性胰腺炎。将全部胰腺粉碎后，将每只犬的全部胰岛细胞分别移植到每只犬的脾髓内。胰腺纤维化严重的犬胰岛移植后内分泌功能紊乱，血糖不能维持正常。2）节段性胰腺移植是否需要胰管引流？11只犬在全胰切除后行胰肠吻合或胰囊吻合的节段性胰腺移植。所有犬均表现出正常的内分泌功能，长期无胰腺F ...更多信息伊布罗病8只犬行胰腺节段移植术后，均出现进行性胰腺功能障碍，并伴有严重的纤维化。3）如何预防节段胰腺移植术后脾静脉血栓形成？15只犬行带脾或不带脾脾动静脉分流的节段性胰腺移植。在这种狗中。未见血管血栓形成。B）临床研究：在上述实验结果的基础上，对4例慢性胰腺炎和5例胰十二指肠癌患者进行了自体胰岛移植和节段性胰腺移植。4例慢性胰腺炎患者行胰体尾次全切除联合胰岛移植术，3例胰十二指肠癌患者行全胰切除联合胰岛移植术。1例胰腺癌患者行带脾全胰切除术后行自体胰腺节段移植，1例不带脾全胰切除术后行自体胰腺节段移植，7例胰岛移植患者行术后胰腺内分泌功能检查。与术前相比，5例逐渐紊乱，2例无变化。2例节段性自体胰腺移植，1例因脾静脉血栓形成而丢失，另1例术后存活，胰腺功能正常。少