New Tumor Imaging with porphyrin derivatives which have high tumor-tissue affinity.

使用具有高肿瘤组织亲和力的卟啉衍生物进行新的肿瘤成像。

• 批准号: 60480312
• 负责人: NAKAJIMA Susumu
• 金额: $ 3.78万
• 依托单位: Asahikawa Medical college
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480312/
• 关键词: Porphyrin derivatives; Tumor tissue accumulation; Ga-67 citrate; New tumor positive scintigraphy; Bacterio-pheophorbide

Since 1978,our group has examined porphyrin derivatives based on hemoglobin and chlorophyl and their metal complexes(160 in all) and tested their relationships between side chain structure and tumor tissue accumulation. Based on this research,our group started developing new tumor-positive chemicals for scintigraphic use that would improve the diagnosis and treatment of lung cancers.Recently developed In-111-mono-DTPA-Ethyleneglycol Ga deuterporphyrin(In-111-MDEGD) were applied to Syrian golden hamsters with implanted pancreatic gland cancers,C57-black mice with Lewis lung cancer and nude mice with human lung adenocarcinoma to enable tumor imaging and biodistribution examination.In the resutant data, In-111-MDEGD showed larger tumor/lung,tumor/kidney and tumor/ blood ratio than with Ga-67-citrate. The affinity of In-111-MDEGD in inflammatory tissue was much lower than that of Ga-67-citrate.Recently we also found new photosensitizer-(bacterio-pheophorbide)which has maximum absorbance wavelength at 755nm.

自1978年以来，课题组对基于血红蛋白和叶绿素的卟啉衍生物及其金属配合物（共160个）进行了研究，并测试了它们的侧链结构与肿瘤组织积累的关系。基于这项研究，我们课题组开始开发用于闪烁显像的新型肿瘤阳性化学物质，以改善肺癌的诊断和治疗。最近开发的In-111-单-DTPA-乙二醇Ga次卟啉（In-111-MDEGD）应用于患有植入性胰腺癌的叙利亚金仓鼠、患有Lewis肺癌的C57-黑小鼠 癌症和人肺腺癌裸鼠进行肿瘤成像和生物分布检查。在结果数据中，In-111-MDEGD显示出比Ga-67-柠檬酸盐更大的肿瘤/肺、肿瘤/肾和肿瘤/血液比率。 In-111-MDEGD在炎症组织中的亲和力远低于Ga-67-柠檬酸盐。最近我们还发现了新的光敏剂——细菌脱镁叶绿酸，其最大吸收波长为755nm。

项目成果

中島進: 肺癌.

中岛进：肺癌。

中島進: 画像情報.

中岛进：图像信息。

Nakajima Susumu et all.: "TUMOR :IMAGING WITH In-111-MONO DTPA-EG Ga DEUTER PORPHYRIN" Lung Cancer (Japanese). in press.

Nakajima Susumu 等人：“肿瘤：使用 In-111-MONO DTPA-EG Ga DEUTER PORPHYRIN 进行成像”肺癌（日语）。

Nakajima Susumu et all.: "Tumor Imaging of Lung Cancer with In-111-MDEGD - a comparative study of Ga-67-citrate -" Imaging Infomation (Japanese). in press.

Nakajima Susumu 等人：“In-111-MDEGD 的肺癌肿瘤成像 - Ga-67-柠檬酸盐的比较研究 -”成像信息（日语）。

中島進: 医学のあゆみ.

中岛进：医学史。