New Tumor Imaging with porphyrin derivatives which have high tumor-tissue affinity.

自1978年以来，我们小组研究了基于血红蛋白和叶绿素的卟啉衍生物及其金属络合物(总共160个)，并测试了它们的侧链结构与肿瘤组织聚集之间的关系。在这项研究的基础上，我们的团队开始开发新的肿瘤阳性化学物质，用于提高肺癌的诊断和治疗。最近开发的In-111-单-DTPA-乙二醇镓二氢卟啉(In-111-MDEGD)被应用于移植胰腺癌的叙利亚金黄地鼠、Lewis肺癌的C57黑鼠和人类肺腺癌的裸鼠，以实现肿瘤成像和生物分布检查。在恢复的数据中，In-111-MDEGD显示出比Ga-67-柠檬酸盐更大的肿瘤/肺、肿瘤/肾脏和肿瘤/血液比。In-111-MDEGD在炎症组织中的亲和力远低于Ga-67-柠檬酸盐。最近我们还发现了新的光敏剂--脱镁叶绿酸细菌，其最大吸收波长为755 nm。

Since 1978,our group has examined porphyrin derivatives based on hemoglobin and chlorophyl and their metal complexes(160 in all) and tested their relationships between side chain structure and tumor tissue accumulation. Based on this research,our group started developing new tumor-positive chemicals for scintigraphic use that would improve the diagnosis and treatment of lung cancers.Recently developed In-111-mono-DTPA-Ethyleneglycol Ga deuterporphyrin(In-111-MDEGD) were applied to Syrian golden hamsters with implanted pancreatic gland cancers,C57-black mice with Lewis lung cancer and nude mice with human lung adenocarcinoma to enable tumor imaging and biodistribution examination.In the resutant data, In-111-MDEGD showed larger tumor/lung,tumor/kidney and tumor/ blood ratio than with Ga-67-citrate. The affinity of In-111-MDEGD in inflammatory tissue was much lower than that of Ga-67-citrate.Recently we also found new photosensitizer-(bacterio-pheophorbide)which has maximum absorbance wavelength at 755nm.