Dental Materials inherited anti-plaque adhesion

牙科材料遗传性抗牙菌斑粘附

• 批准号: 60480424
• 负责人: ATSUTA Mitsuru
• 金额: $ 4.1万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480424/
• 关键词: Dilated Delivery System; Antiplaque Agent; Flavanone; Chlorhexidine; Irgasan; Thermosetting Acrylic Resin; Crude Drug; 硬質レジン

The purpose of the investigation is to apply DDS (dilated delivery system) to the dental clinical medicine. More than fifty kinds of antiplaque agents and kindred drugs, which chiefly extracted from herbs, were added to the dental materials. The efficacy of eluted drugs were confirmed by the bioassay. The results were as follows:1. The effects of adding drugs on the physical properties of the polymers; Drugs dissolved readily in the monomers had a tendency to give good physical properties of the polymers. Flavanone added to MMA and 2.6E monomer decreased remarkably the amount of water sorption of the polymers, whereas increased that of polymerized UDMA. To elute the chlorhexidine in distilled water at 37゜C for 3 months decreased severely the physical properties, whereas the flavanone increased them slightly.2. The measurement of the amount of drugs eluted in water; The chlorhexidine having a concentration of 3% in the polymers eluted 15ug/day per the polymer of 0.1g after immersion in the distilled water for 1 month. The Irgasan eluted from the 2.6E polymer was much more than that of MMA. The effluent of the flavanone was at a concentration of about 2% even after the accelated immersion test in water at 60゜C for 10 hours.3. Antiplaque effects of the drugs delivered in water; The chlorhexidine added to the resin in the ratio of 3% inhibited the growth of S.mutans even after immersion in water for 7 weeks. The Irgasan at concentration of 10 to 20% could not inhibit the growth of C.albicans after immersion in water for 2 to 6 months, although the cells suffered damage partially were observed with SEM. The flavanone which was added at high concentration of 50%, inhibited the growth of S.mutans at the ratio of about 10%. The toxicity of drugs eluted to the human tissue cells depended upon the quality, not quantity of drugs.

本研究的目的是将DDS（dilated delivery system）应用于口腔临床医学。在牙科材料中添加了50多种主要从中草药中提取的抗牙菌斑剂及同类药物。通过生物测定证实了洗脱药物的功效。结果如下：1.药物的加入对聚合物物理性能的影响药物易溶于单体中，聚合物的物理性能较好。在MMA和2.6E单体中加入黄烷酮，可显著降低聚合物的吸水量，而增加聚合UDMA的吸水量。氯己定在37 ℃的蒸馏水中浸泡3个月，其物理性质严重下降，而黄烷酮则略有增加.药物在水中洗脱量的测定：聚合物中浓度为3%的氯己定在蒸馏水中浸泡1个月后，每0.1g聚合物洗脱15 μ g/天。从2.6E聚合物洗脱的Irgasan比MMA多得多。即使在60 ° C的水中加速浸泡测试10小时后，黄烷酮的流出物的浓度也为约2%。水中给药的抗牙菌斑作用：在树脂中加入3%的洗必泰，即使在水中浸泡7周后，也能抑制变形链球菌的生长。10%~ 20%的Irgasan在水中浸泡2 ~ 6个月后，对白念珠菌的生长无抑制作用，但扫描电镜观察到白念珠菌细胞有部分损伤。添加50%的黄烷酮对变形链球菌生长的抑制率约为10%。洗脱药物对人体组织细胞的毒性取决于药物的质量，而不是数量。