Dental Materials inherited anti-plaque adhesion

研究的目的是应用DDS （分流输送系统）到牙科临床医学。还有五十种抗生素和幼儿药物，从草药中提取的蝴蝶，已经添加到牙科材料中。《生物试验》证实了被淘汰的药物的有效性。结果如以下所示：1。药物对聚合物的物理特性的影响;单体中的药物似乎有一种趋势，以提供良好的物理特性。Flavanone被添加到MMA和2.6 E单体decreased remarkably the polymers的水吸收量，其中增加了聚合UDMA。为了在37 ° C的溶解水中使用氯己定，3个月的时间里，当黄酮被稀释到严重的物理性质时，它们被稀释了。对水中提取的药物量的测量;在1个月的水中浸泡的聚合物中，每15微克/天使用0.1克的聚合物的氯己定有3%的浓度。从2.6 E聚合物中提炼出的伊加森比MMA的多。呋喃酮的有效性在10小时后，在60 ° C的水中进行了加浸试验，即使在2%左右。药物在水中输送的抗干扰效应;氯己酮添加到沉积物在沉积物中的比率为3%，甚至在7周后抑制了S. mutans在水中浸泡的增长率。在伊利诺伊州的集中度为10 - 20%，不能抑制C.阿尔比坎在水中浸泡2 - 6个月后的增长，也可能造成与SEM相关的部分损害。“香草”被添加到50%的高浓度，抑制了S.变种人的增长率约为10%。“药物的毒性被剥夺了人类组织细胞依赖于质量，而不是药物的数量。”

The purpose of the investigation is to apply DDS (dilated delivery system) to the dental clinical medicine. More than fifty kinds of antiplaque agents and kindred drugs, which chiefly extracted from herbs, were added to the dental materials. The efficacy of eluted drugs were confirmed by the bioassay. The results were as follows:1. The effects of adding drugs on the physical properties of the polymers; Drugs dissolved readily in the monomers had a tendency to give good physical properties of the polymers. Flavanone added to MMA and 2.6E monomer decreased remarkably the amount of water sorption of the polymers, whereas increased that of polymerized UDMA. To elute the chlorhexidine in distilled water at 37゜C for 3 months decreased severely the physical properties, whereas the flavanone increased them slightly.2. The measurement of the amount of drugs eluted in water; The chlorhexidine having a concentration of 3% in the polymers eluted 15ug/day per the polymer of 0.1g after immersion in the distilled water for 1 month. The Irgasan eluted from the 2.6E polymer was much more than that of MMA. The effluent of the flavanone was at a concentration of about 2% even after the accelated immersion test in water at 60゜C for 10 hours.3. Antiplaque effects of the drugs delivered in water; The chlorhexidine added to the resin in the ratio of 3% inhibited the growth of S.mutans even after immersion in water for 7 weeks. The Irgasan at concentration of 10 to 20% could not inhibit the growth of C.albicans after immersion in water for 2 to 6 months, although the cells suffered damage partially were observed with SEM. The flavanone which was added at high concentration of 50%, inhibited the growth of S.mutans at the ratio of about 10%. The toxicity of drugs eluted to the human tissue cells depended upon the quality, not quantity of drugs.