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Role of central nervous sytem in the changes in pulmonary hemodynamics and vascular permeability

中枢神经系统在肺血流动力学和血管通透性变化中的作用

基本信息

批准号：
60480473
负责人：
ISHIKAWA Naohisa
金额：
$ 4.22万
依托单位：
Department of Pharmacol., Nagoya University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

Roles of pulmonary innervation in the changes in pulmonary hemodynamics and vascular permeability were investigated. First, we studied the effects of changes in hemodynamic parameters on the bronchopulmonary anastomotic blood flow, in a canine dual perfusion preparation in which the pulmonary and systemic circulations were separately perfused. Obtained results indicated that the sympathetic nerves play a role in reducing the changes in the bronchopulmonary anastomotic blood flow caused by a change in left atrial pressure and systemic arterial pressure. In systemic hypertension, it is likely that the bronchopulmonary anastomotic blood flow is less affected by the systemic arterial pressure, via an enhanced sympathetic nervous activity as weel as via a rise in left atrial pressure. It has been suggested that the bronchial venous bed is affected by the sympathetic nervous tone. Secondly, pulmonary edema was caused by infusing serotonin, in dogs. Especially the serotonin receptor subtypes … More were evaluated in terms of the roles in the changes in pulmonary hemodynamics and development of pulmonary edema. It was suggested that S_2 receptor participated in a rise in pulmonary vascular beds, whereas S_1 receptor participated in an increase in vascular permeability.Last, since it has been suggested that lung innervation play a role in the development of pulmonary edema, effects of several receptor antagonists in the development of pulmonary edema were investigated. As a neurogenic pulmonary edema, we studied the fibrin-induced pulmonary edema. We examined the effects of several experimental conditions on the incidence and severity of pulmonary edema in rats. An experimental condition where the fibrin-induced pulmonary edema happens at a rate of 100 %, was found to be as follows; 6.5 of pH in solution injected intracisternally and vagotomy. By using such an experimental condition, we fount that neither radical scavenger anti-histamine and acetylcholine nor corticosteroid prevented the edema formation. Less

探讨肺神经支配在肺血流动力学和血管通透性改变中的作用。首先，我们研究了血流动力学参数的变化对犬双侧肺和体循环分别灌流的支气管-肺吻合口血流量的影响。结果表明，交感神经在减轻左心房压和体动脉压改变引起的支气管-肺吻合口血流量改变中起作用。在全身性高血压中，通过交感神经活动的增强以及左房压力的升高，很可能支气管-肺吻合口的血流量受全身动脉压的影响较小。已有研究表明，交感神经张力对支气管静脉床有影响。其次，注入5-羟色胺引起了狗的肺水肿。尤其是5-羟色胺受体亚型…更多的是根据在肺血流动力学改变和肺水肿发展中的作用进行评估。提示S_2受体参与了肺血管床的升高，而S_1受体参与了血管通透性的增加。最后，鉴于已有研究表明肺神经支配在肺水肿的发生发展中起作用，我们探讨了几种受体拮抗剂在肺水肿发生发展中的作用。作为一种神经源性肺水肿，我们对纤维蛋白所致肺水肿进行了研究。我们考察了几种实验条件对大鼠肺水肿发生率和严重程度的影响。纤维蛋白所致肺水肿发生率为100%的实验条件为：池内注射pH为6.5的溶液，切断迷走神经。在这样的实验条件下，我们发现自由基清除剂抗组胺、乙酰胆碱和皮质类固醇都不能阻止水肿的形成。较少