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A NEW SEPARATION MECHANISM OF CENTRIFUGAL PARTITION CHROMATOGRAPHY ASSOCIATED WITH LIQUID MEMBRANE TRANSPORT SYSTEM.

液膜传输系统离心分配色谱新分离机制。

基本信息

批准号：
61470026
负责人：
ARAKI Takeo
金额：
$ 4.48万
依托单位：
Shimane University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

The investigators have found that when a separator is added to the Centifugal Partition Chromatography (CPC), its separation mechanism becomes to be similar to that of liquid membrane transport (LMT) systems. The main research project of this fund was concentrated on the extension of this new mechanism to the problems of separation/concentration/isolation of materials, and to clarify the relation between the "separator-aided CPC" and LMT systems. The apparatus employed was Sanki Engi-neering CPC-L.L. (Model NMF).In considering the mechanistic similarity and difference of these two techniques, a correla-tion guideline table was constructed. Direct comparison between the CPC and LMT using nitrophenols (2,4,6-trinitrophenol and p-nitro-phenol) as aqueous sample solution, and n-butanol as separator in chloroform solvent. In both technique stronger interaction with n-butanol was observed for p-nitro-phenolthan for 2,4,6-trinitrophenol. NMR spectroscopically pure fractions could readily be o … More btained by CPC from the equimolar mixture sample. At the same time, selective LMT was attained using simple and costless "carrier", i.e.. n-butanol. Hence, the CPC can be regarded as a new type of multistage LMT system. Similar relation between separator-aided CPC and LMT was observed for rare earth metal ion (RE^<3+>) samples when Di-(2-ethylhexyl)phosphoric acid (D2EHPA), a familiar extractant of these ions, was used as separator. The interaction of the RE^<2+> ions with D2EHPA in CPC and LMT was found to obey a simple equilibrium known in the corresponding extraction processes. then, by adjusting the factors which affect the equilibrium, CPC separation of righter RE^<3+> ions was attained relatively readily. Also, selective LMT of the various sets of RE^<3+> ions was realized by the use of D2EHPA. Since the separation mechanism involved in these cases is essentially acid-base type interaction. The peak broadening in CPC became significant with increase of the RE's atomic number, especially for heavier RE^<3+> ions. However, the relation between CPC and LMT was retained throughout. Further extension was attempted to opitical resolution in CPC, and fundamental pre-requisites for effective resolution by CPC wre tabulated. We are now continuing trying experimentally along this pre-requi-sites. Thus, the investigators were capable of showing high utillity of the separator-aided CPC and the applicavility of these CPC data to costless sensing procedures using liquid membranes. Less

研究人员发现，当分离器被添加到离心分配色谱（CPC）中时，其分离机理变得与液膜传输（LMT）系统相似。该基金的主要研究项目集中于将这种新机制扩展到材料的分离/浓缩/隔离问题，并澄清“分离器辅助CPC”和LMT系统之间的关系。所用仪器为Sanki Engi-neering CPC-L.L.（NMF模型），考虑到这两种技术在机理上的相似性和差异性，建立了相关准则表。在氯仿溶剂中，以硝基酚（2，4，6-三硝基酚和对硝基酚）为样品水溶液，正丁醇为分离剂，直接比较了CPC和LMT。在这两种技术中，对硝基苯酚与正丁醇的相互作用比2，4，6-三硝基苯酚强。NMR光谱纯级分可以容易地被分离。 ...更多信息通过CPC从等摩尔混合物样品中获得。同时，选择性LMT是通过使用简单和廉价的“载体”，即。正丁醇。因此，CPC可以被视为一种新型的多级LMT系统。以稀土离子（RE^<3+>）的常用萃取剂二-（2-乙基己基）磷酸（D2 EHPA）为分离剂时，分离剂辅助CPC与LMT之间存在相似的关系。在CPC和LMT中，RE^<2+>离子与D2 EHPA的相互作用遵循一个简单的平衡，这在相应的萃取过程中是已知的。然后通过调整影响平衡的因素，使CPC较容易地分离较正的RE^<3+>离子。此外，通过使用D2 EHPA实现了不同RE^<3+>离子组的选择性LMT。因为在这些情况下涉及的分离机理基本上是酸-碱型相互作用。随着RE原子序数的增加，CPC的峰宽明显变宽，特别是对于较重的RE^<3+>离子。然而，CPC和LMT之间的关系始终保持不变。本文试图对CPC的光学解决方法作进一步的拓展，并列举了CPC有效解决问题的基本前提。我们现在正继续沿着这个先决条件进行实验性的沿着尝试。因此，研究人员能够显示分离器辅助CPC的高效用以及这些CPC数据对使用液膜的无成本感测程序的适用性。少