Studies on increasing sensitivities in pulpal inflammatory reactions by new inflammatory mediator(PAF)

一些兴奋剂很容易在牙髓组织中引起炎症反应。我们已经报道，在牙髓中检测到组胺和其他炎症诱变因子，这可能在炎症过程中发挥作用。PAF。研究了一种新型炎症介质在牙髓炎症中的意义。在大鼠牙髓组织中检测到PAF。PAF刺激大鼠牙髓组织释放PGI_2、GT、TXA_2。事实表明，内皮细胞起着重要的作用。在动脉平滑肌，PAF增强了对肾上腺素的收缩反应。在其他肌肉中未发现这种增强作用。在神经元性炎症(坐骨神经相互电刺激实验)中，PAF不能增强这种反应，而是在内皮细胞存在的情况下增加毛细血管通透性。在体内神经肌肉制剂中，PAF.4的预处理抑制了对抗尿剂的松弛作用，这也支持了这一事实。在肺呼吸阻力实验中，PAF引起的气管收缩增加可被抗PAF药物、抗过敏药物和B_1相关化合物所拮抗。这些拮抗剂不影响血小板聚集活性。因此，上述结果提示，在牙髓组织的初始炎症过程中，PAF可能在炎症条件的预安排的形成中起作用，PAF诱导的炎症条件可能是非常强烈的介质的释放和作用。

Some stimulants evoke easily an inflammatory reactionin the pulp tissue. We have reported that histamine and other inflammatory muediators were detected in the pulp and that may be play a role in the inflammatory process. PAF. a new inflammatory mediator, was studied on the signification in pulpal inflammation.1. PAF was detected in pulpal tissue of rats. And PAF stimulated PGI_2>TXA_2 release from rat pulppal tissue. The fact suggests that the endothelial celles play a important role.2. In the arterial smooth muscle, PAF potentiated the contracted reaction toadrenaline. The potentiation was not found in other smooth muscles.3. In neuronal inflammation ( reciprocal electrical stimulation experiments in the sciatic nerve), PAF did not potentiate the reaction, and it increased thecapillary permeability under the existence of endothelial cells. This also is supported by the fact that in the in vivo nerve-muscle preparation, the relaxant action to anticurare agents is inhibited by pretreatment of PAF.4. In pulmonary respirationresistance experiments, the increase of tracheal contraction with PAF was antagonized by anti-PAF drugs, and also anti- allergic agents and B_1 related compounds. The pulatelet aggregating activity, howoevor, did not be influenced by theseantagonists. Therefore, the above mentionned results suggest that in the initial inflammatory process in the pulpal tissue, PAF may be play a role of the formation of the prearrangements of inflammatory conditions and that the PAF -induced condition may be very intensify the release and actions of mediators.