Interaction of viral and chemical hepatocarcinogenesis

本研究在病毒与化学致癌相互作用的研究中，阐明了以下几点：（1）建立了鸭B肝炎病毒（DHBV）感染致肝癌的动物模型;（B）在病毒致癌方面，观察了DHBV感染3年后肝癌的发展。C）在化学致癌中，肝细胞癌的发展在1 - 2年内观察到，略早于病毒致癌。C）在病毒和化学致癌结合中，肿瘤的发展在1 - 2年内观察到，类似于化学致癌。然而，在任何肿瘤中均未观察到DHBV DNA的整合。病毒和化学致癌似乎有不同的发展途径的肝细胞癌。DHBV整合入宿主基因组可能是病毒相关肿瘤发生的先决条件。

We have elucidated the following in the study of interaction of viral and chemical hepatocarcinogenesis.A) We have established an model from duck hepatitis B virus (DHBV) infection to hepatocarcinogenesis.B) In viral oncogenesis, the development of hepatocellular carcinoma was observed after 3 years of infection. DHBV DNA was integrated in the majority of the tumor.C) In chemical oncogenesis, the development of hepatocellular carcinoma was observed in one to two years, somewhat earlier thail viral oncogenesis.C) In viral and chemical oncogenesis combined, the development of the tumor was observed in one to two years, similar to chemical carcinogenesis.However, integration of DHBV DNA was not observed in any of the tumors.In conclusion, viral and chemical oncogenesis seems to have different pathway of development of hepatocellular carcinoma. Integration of DHBV into host genome may be prerequisite for virus related oncogenesis.