Diagnostic and Nosological Study on Developmental Disorders Related to Infantile Autism

婴儿自闭症相关发育障碍的诊断和疾病学研究

• 批准号: 63480263
• 负责人: KURITA Hiroshi
• 金额: $ 1.98万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480263/
• 关键词: Developmental regression; Disintegrative disorder; Disintegrative psychosis; Infantile autism; Pervasive developmental disorder; Rating scale; 診断; 疾病分類; 発達障害; 自閉傾向

To conduct this study, we developed three rating scales. The first one, the Childhood Autism Rating Scale--Tokyo Version (CARS-TV) demonstrated satisfactory taxonomic validity on DSM-III diagnostic groups. Cronbach's alpha was .87. An average interrater reliability (r) was .62. The next, the Tokyo Autistic Behavior Scale (TABS) showed a satisfactory test-retest reliability (r for the total score was .94). Cronbach's alpha was .78. The total TABS score was significantly higher in infantile autism (IA) than in other five DSM-III groups. A value of r between total scores of the TABS and the CARS-TV was .59. The third, the Checklist for Autistic Tendency (CAT) showed satisfactory split-half reliability and concurrent validity to the DSM-III groups.The total CARS-TV score was significantly lower in 57 Other Pervasive Developmental Disorders (OPDDs) than in 39 IAs. OPDDs were significantly less impaired than IAs in two CARS-TV scales : Visual responsiveness and general impressions. The total and nine item TABS scores indicated that OPDD was significantly less impaired than IA.Development before regression was better in 15 disintegrative psychosis (DP) cases than sex- and age-matched 30 IAs having had similar regression. But it was not entirely normal in more than half of the DPs as some of such historical cases. After regression, DPs had significantly lower mental development level than IAs. The total CARS-TV score did not differ significantly between DPs and IAs. We suggested a phrase "apparent normal development" before regression in the diagnostic criteria for disintegrative disorder (a new name for DP) in ICD-10 draft be replaced with "normal or near normal development." Although OPDD seems milder in intellectual and autistic impairments than IA, it is still a mixture of diverse conditions that need more precise division.

为了进行这项研究，我们制定了三个评级量表。第一个，儿童自闭症评定量表——东京版（CARS-TV）在 DSM-III 诊断组中表现出令人满意的分类学有效性。 Cronbach 的 alpha 值为 0.87。平均评价者间可靠性 (r) 为 0.62。接下来，东京自闭症行为量表（TABS）显示出令人满意的重测信度（总分 r 为 0.94）。 Cronbach 的 alpha 值为 0.78。婴儿自闭症 (IA) 的 TABS 总分显着高于其他五个 DSM-III 组。 TABS和CARS-TV的总分之间的r值为0.59。第三个，自闭症倾向检查表 (CAT) 对 DSM-III 组显示出令人满意的分半信度和同时效度。 57 个其他广泛性发育障碍 (OPDD) 的 CARS-TV 总分显着低于 39 个 IAs。在两个 CARS-TV 量表中，OPDD 的受损程度明显低于 IAs：视觉反应能力和总体印象。总分和九项 TABS 评分表明，OPDD 的受损程度显着低于 IA。15 名瓦解性精神病 (DP) 病例中，回归前的发展优于性别和年龄匹配的 30 名具有类似回归的 IAs。但在超过一半的移民中，这并不完全正常，就像历史上的一些案例一样。回归后，DP 的智力发育水平显着低于 IAs。 DP 和 IAs 之间的 CARS-TV 总分没有显着差异。我们建议ICD-10草案中崩解性障碍（DP的新名称）诊断标准中回归前的短语“表观正常发育”替换为“正常或接近正常发育”。尽管 OPDD 的智力和自闭症障碍似乎比 IA 更轻微，但它仍然是多种病症的混合体，需要更精确的划分。

项目成果

Hiroshi Kurita: "Reliability and Validity of the Childhood Autism Rating ScaleーーTokyo Version(CARSーTV)" Journal of Autism and Developmental Disorders. 19. 389-396 (1989)

Hiroshi Kurita：“儿童自闭症评定量表的可靠性和有效性——东京版（CARS-TV）”《自闭症与发育障碍杂志》19. 389-396（1989）。

Hiroshi Kurita: "Reliability and Validity of the Tokyo Autistic Behavior Scale" The Japanese Journal of Psychiatry and Neurology. 44. (1990)

Hiroshi Kurita：“东京自闭症行为量表的可靠性和有效性”日本精神病学和神经病学杂志。

Hiroshi Kurira: "The Reliability and Validity of the Tokyo Autistic Behavior Scale" The Japanese Journal of Psychiatry and Neurology. 44. 25-32 (1990)

Hiroshi Kurira：“东京自闭症行为量表的可靠性和有效性”日本精神病学和神经病学杂志。

三宅由子: 発達障害研究. 11. (1989)

三宅裕子：发育障碍研究 11。（1989）

Hiroshi Kurita: "A Comparative Study between Disintegrative Psychosis and Infantile Autism" Journal of Autism and Developmental Disorders.

Hiroshi Kurita：“崩解性精神病和婴儿自闭症之间的比较研究”自闭症和发育障碍杂志。