Study on Early Pathology of Senile Disciform Macular Degeneration using a computerized image-processing system

为了对眼底后极老年性病变的早期诊断提供更详细的信息，对61例50岁以上患者的荧光素血管造影图像进行了图像处理，其中38例为老年性黄斑变性ARMD(老年性视盘状黄斑变性)，23例为无脉络膜新生血管的ARMD。为了增强图像的对比度，采用了局部距离修正的空间变化对比度增强，增强后的血管造影显示了比常规血管造影更多的玻璃体，使更小的玻璃体清晰可见，使低质量的血管造影具有更高的分辨率。部分患者可见散在分布的斑点或颗粒状强荧光。这种强荧光可能代表弥漫性玻璃体(Green，W.R.)或基底层沉积(Sarks，S.)。在增强的血管造影中，一些软性黄褐斑显示出不均匀的强荧光。

In order to obtain more detailed information for early stage diagnosis of age- related pathologies at the posterior pole of the eye- ground, an image processing procedure was applied to fluorescein angiographs from 61 patients over 50 years of age : 38 patients with the neovascular type of age-related macular degeneration ARMD (senile disciform macular degeneration SDMD) and 23 patients with ARMD without choroidal neovascularization. For the image processing to enhance contrast, spatially - variant contrast enhancement using local range modification was applied.On the enhanced angiographs larger numbers of drusen were demonstrated than on the regular angiographs, making smaller drusen observable and giving the angiographs of low quality higher resolution. In some patients, widely scattered dot or granular hyperfluorescence became observable. This hyperfluorescence might represent diffuse drusen (Green, W.R.) or basal laminar deposits (Sarks, S.). On the enhanced angiographs some soft drusen came to show lack of uniformity in their hyperfluorescence.