Ultra-high pressure liquid chromatograph

在耶拿弗里德里希·席勒大学，正在进行研究，开发大分子（“软物质”）作为跨学科和院系的纳米医学的基石，结合纳米科学，生物化学，制药，材料科学，聚合物科学和医学。主题“软物质”也在耶拿大学的轮廓线中发挥着核心作用。纳米容器的开发和受控生产做出了重要贡献。为了生产最高质量的纳米物体，在受控的洁净室环境中使用良好生产规范的原则进行配制和表征是必要的。为此，必须详细表征用于配制纳米物质的聚合物起始材料和待包封的活性成分以及最终制备的纳米容器。这些研究的关键技术是灵活的超高压液相色谱（UHPLC），可以准确地检查制造过程前后的各种分析物。这将使新的研究项目和支持现有的研究，这是集中锚定在SFB 1278（“多目标”）：聚合物纳米容器及其在诊断和靶向药物输送中的使用。

At the Friedrich Schiller University Jena, research is being conducted on the development of macromolecules ("soft matter") as building blocks of nanomedicine across disciplines and faculties, combining nanosciences, biochemistry, pharmacy, materials science, polymer science and medicine. The topic "Soft Matter" also plays a central role in the profile lines of the University of Jena. The development and controlled production of nanocontainers make an important contribution. For the production of highest quality nano-objects, the formulation and characterization in a controlled clean room environment using the principles of good manufacturing practice is imperative. For this, both the polymeric starting materials used for the formulation of the nanoobjects and the active ingredients to be encapsulated as well as the finally produced nanocontainers must be characterized in detail. The key technology for these investigations is a flexible ultra-high-pressure liquid chromatography (UHPLC), with which a wide variety of analytes before and after the manufacturing process can be checked accurately. This will enable new research projects and support existing research, which is centrally anchored in SFB 1278 ("PolyTarget"): Polymers for nanocontainers and their use in diagnostics and targeted drug delivery.