Ultra-high pressure liquid chromatograph

在耶拿的弗里德里希·席勒大学，正在进行将纳米科学、生物化学、药剂学、材料科学、聚合物科学和医学结合在一起的大分子(“软物质”)的开发，作为跨学科和院系的纳米医学的基石。“软物质”这一话题在耶拿大学的简介中也扮演着核心角色。纳米容器的开发和受控生产做出了重要贡献。为了生产高质量的纳米物体，在受控的洁净室环境中使用良好制造实践的原则进行配方和表征是势在必行的。为此，用于配制纳米对象的聚合物起始材料和要被包裹的活性成分以及最终生产的纳米容器都必须进行详细的表征。这些研究的关键技术是一种灵活的超高压液相色谱(UHPLC)，利用它可以准确地检查制造过程前后的各种分析物。这将支持新的研究项目，并支持集中在SFB 1278(“PolyTarget”)中的现有研究：用于纳米容器的聚合物及其在诊断和靶向药物输送中的用途。

At the Friedrich Schiller University Jena, research is being conducted on the development of macromolecules ("soft matter") as building blocks of nanomedicine across disciplines and faculties, combining nanosciences, biochemistry, pharmacy, materials science, polymer science and medicine. The topic "Soft Matter" also plays a central role in the profile lines of the University of Jena. The development and controlled production of nanocontainers make an important contribution. For the production of highest quality nano-objects, the formulation and characterization in a controlled clean room environment using the principles of good manufacturing practice is imperative. For this, both the polymeric starting materials used for the formulation of the nanoobjects and the active ingredients to be encapsulated as well as the finally produced nanocontainers must be characterized in detail. The key technology for these investigations is a flexible ultra-high-pressure liquid chromatography (UHPLC), with which a wide variety of analytes before and after the manufacturing process can be checked accurately. This will enable new research projects and support existing research, which is centrally anchored in SFB 1278 ("PolyTarget"): Polymers for nanocontainers and their use in diagnostics and targeted drug delivery.