Enzyme-like FLP Catalysis within Coordination Cages

配位笼内的类酶 FLP 催化

• 批准号: 439667829
• 负责人: Dr. Weichao Xue
• 金额: --
• 依托单位: Yusuf Hamied Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/439667829?language=en
• 关键词: Enzyme; like; FLP; Catalysis; within

The project aims to achieve the encapsulation of frustrated Lewis pairs (FLPs) by water-soluble coordination cages. This would provide the first example of coordination cages incorporating FLP catalysts, advancing the field of enzyme-mimic catalysis. The successful execution of this project will overcome the problem that FLP catalysis cannot proceed in aqueous solution, and at the same time bring about improved reactivity and unprecedented selectivity for FLP catalysis with the aid of coordination cages. This will also open new avenues to apply cage catalysis and FLP catalysis to other fundamental organic reactions.

该项目旨在实现水溶性配位笼对受挫折的刘易斯对（FLP）的封装。这将提供结合FLP催化剂的配位笼的第一个例子，推进酶模拟催化领域。该项目的成功实施将克服FLP催化不能在水溶液中进行的问题，同时借助配位笼提高FLP催化的反应活性和前所未有的选择性。这也将为笼催化和FLP催化应用于其他基本有机反应开辟新的途径。