The Role of Immure Cells in Liver Metastasis of Paucreatic Cariroma

胰腺癌患者LAK细胞对NK敏感细胞的杀伤活性为77.9%，对LAK敏感细胞的杀伤活性为72.9%，对培养的人胰腺癌细胞系PK-1、PK-9、KLM-1的杀伤活性分别为36.7%、23.2%、86.4%。LAK细胞对裸鼠体内接种KLM-1细胞的生长有抑制作用。从胰腺癌患者体内可获得对胰腺癌细胞具有高杀伤活性的LAK细胞。肝细胞表面的层粘连蛋白和纤维连接蛋白可介导胰腺癌细胞在肝转移早期的附着和迁移。高转移性突变体(KLM-1)所形成的肝转移模型对于研究人胰腺癌的肝转移过程具有重要价值。

The killing activities of LAK cells obtained from pancreatic cancer patients were 77.9% for NK sensitive cells, 72.9% for LAK sensitive cells, and 36.7%, 23.2%, 86.4% for cultured human pancreatic cancer cell lines PK-1, PK-9, and KLM-1 respectively. The growth of KLM-1 cells inoculated on nude mice was inhibited by LAK cells in vivo. LAK cells with high killing activity against pancreatic cancer cells can be obtained from patients with pancreatic cancer. Laminin and fibronection on the surface of hepatocytes can mediate pancreatic cancer cells attachment and migration in the early phase of liver metastasis. The liver metastasis model formed by a highly metastatic variant (KLM-1) is valuable for the study of the liver metastatic processes of human pancreatic cancer.