Autologous blood transfusion using recombinant human erythropoietin in gastrointestinal surgery.

在胃肠道手术中使用重组人促红细胞生成素进行自体输血。

• 批准号: 04670747
• 负责人: MAEDA Hiroo
• 金额: $ 1.28万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670747/
• 关键词: Gastrointestinal surgery; Adverse effects of transfusion; Autologous blood transfusion; Erythropoietin

To prevent adverse effects of homologous blood transfusion (HBT), we administered recombinant human erythropoietin (EPO) to the patients undergoing gastrointestinal surgery couples with or without autologous blood donation (ABD). We also measured the endogenous EPO in these patients.1) The EPO level in cancer patients tested was found relatively lower than that in patients with iron deficiency anemia.2) Daily administration of recombinant EPO (3,000-6000 IU) for 7 days prior operation raised Hb consentration in patients by approximately 1.0 g/dl.3) Autologous blood deposit (400-600 ml) coupled with adoministration of EPO (3000 IU) also raised Hb concentration increment by 0.8 g/dl, which was essentially same with that of EPO adoministration alone. However, since autologous blood deposit induces medical staffs not to perform HBT and administration of EPO substantially raises Hb concentration, autologous blood donation together with administration of recombinant EPO promises reduction and thereby prevention of adverse effects of HBT.

为了预防同源输血（HBT）的不良反应，我们对有或没有进行自体献血（ABD）的胃肠手术患者给予重组人促红细胞生成素（EPO）。我们还测量了这些患者的内源性EPO。1)癌症患者EPO检测水平低于缺铁性贫血患者。2)术前7天每天给药重组EPO （3000 -6000 IU）可使患者Hb浓度提高约1.0 g/dl。3)自体血沉积（400-600 ml）联合给药EPO （3000 IU）也可使Hb浓度增加0.8 g/dl，与单独给药EPO基本相同。然而，由于自体血沉积导致医护人员不进行HBT，而给药EPO大大提高了Hb浓度，因此，自体献血与给药重组EPO有望减少HBT，从而预防HBT的不良反应。

项目成果

H.Maeda, et al.: "Current status of autologous blood transfusion in orthopedic surgery and application of recombinant human erythropoietin" J.Jap.Soc.Autotransfusion. 6. 6-10 (1993)

H.Maeda 等：“骨科手术中自体输血的现状及重组人促红细胞生成素的应用”J.Jap.Soc.Autotransfusion。

前田平生 他: "整形外科領域における貯血式自己血輸血の現状とEPO投与の適応" 自己血輸血. 6. 6-10 (1993)

Hirao Maeda 等：“骨科领域储存的自体输血的现状和 EPO 给药的适应症”自体输血。 6. 6-10 (1993)。

藤野 幸夫: "消化器外科領域における自己血輸血-recombinaut human erythropoietinを併用して-" 自己血輸血. 4. 191-195 (1992)

Yukio Fujino：“胃肠外科领域的自体输血 - 使用重组人促红细胞生成素 -”自体输血 4. 191-195 (1992)。

前田平生 他: "整形外科領域における貯血式自己血輸血施行手術患者に対するEpocltの評価" 現代医療. 25(増). 1068-1086 (1993)

Hirao Maeda 等人：“Epoclt 对骨科手术领域接受自体输血的手术患者的评估”Gendai Medical，1068-1086 (1993)。

N.Murata, et al.: "Usefulness of autologous blood transfusion in gastrointestinal surgery" J.Jap.Soc.Autotransfusion. 6. 61-65 (1993)

N.Murata 等人：“自体输血在胃肠道手术中的用途”J.Jap.Soc.Autotransfusion。