Pathological differences in oseoporosis following menopause or oophorectomy

分析绝经后骨质疏松症与卵巢切除后骨质疏松症的骨代谢及骨密度(BMD)的变化。研究对象中，绝经或卵巢切除对VONE代谢有明显影响的时间平均为3年，被认为对骨代谢有强烈影响的雄烯二酮和E_1水平在绝经组显著高于卵巢切除组。然而，绝经期受试者中的类固醇优势并没有反映在骨代谢上。任何测量方法(MD、QCT、DPA、DXA)或任何测量部位(外周骨/中枢骨、松质骨/皮质骨)，两组受试者之间的BMD均无显著差异。因此，骨质疏松与卵巢切除相关，引起骨质剧烈改变，临床上被认为是与绝经后骨质疏松相关的生理现象。然而，Junan受试者的临床异质性可能掩盖了更年期和卵巢切除对骨骼反应的细微个体差异。因此，体外研究是必要的，尽管只有初步结果可用，但我们已经注意到骨髓细胞对卵巢切除的反应在数量和质量上的差异。这些发现将在未来的研究中得到跟进。

Enodocinological dynamics, bone metabolism and bone mineral density (BMD) were and analyzed to study whether or not there aer pathological differences in osteoporosis following menopause and that following oophorectomy. Subjects in whom a mean period of 3 years had passed since menopause or oophorectomy, a time when effects on vone metabolism should be evident, were studied, Levels of androstenedione and e_1, considered to have a fanorable effect on bone matabolism, were significantly higher in menopausal subjects compared with subjects undergoing oopherectomy. Howeever, steroid dominance in the menopausal subjects was not reflected in bone metabolism. Nosignificant dirrerence in BMD was detected between the two subject groups by any determination method (MD, QCT, DPA, DXA) or for any site measured (peripheral bone/axial bone, travecular bone/cortical bone). Therefore, osteoporesis associated with oophorectomy, causing drastic changes in bone, ws clinically considered to be comparable to osteoporosis associated with the physiological phenomenon if menopause. However, clinical heterogeneity in junan subjects may mask fine individual differences in the response of bone to menopause and oophorectomy. Invitro research is therefore necessary, Although only preliminary results are available, we have noted quantitative and qualitative differnces in the response of bone marrow cells to oophorectomy. These findings will be followed up by future reseatch.