Development of the concentration and separation system for multi-compornents by ion-pair phase separation phenomena with fluorosurfactant

通过全氟辛酸根离子的电中和发现了两种新的三相分离现象;在中性至碱性溶液中为胺类，在酸性溶液中为极性有机溶剂型。几种金属的浓缩和分离-基于从这些相分离现象获得的基本发现，详细讨论了螯合物和生理活性底物。胺型在pH值为7 ~ 8的范围内，均存在三相分离现象，各相依次为水相和两种不溶于水的相将利用这些现象的均相液-液萃取方法应用于三种组分，例如L-抗坏血酸、血红蛋白和α、β、γ，δ-四（4-三甲基氨基苯基）卟啉（TTMAPP）假设分离人体内的药物物质B ...更多信息 结果，它们能够被分离成水。（L-抗坏血酸），第二在极性有机溶剂类型中，在第一（血红蛋白）和第一（TTMAPP）相中，分别仅使用向全氟辛酸溶液中添加戊胺的一步法。（例如在二甲亚砜存在下的情况），在pH值为0.42 ~ 0.46的范围内，证实了三相分离现象。将此萃取方法应用于八种合成的水溶性卟啉，结果表明，分别在水相、第二相和第一相中对3种水溶性卟啉进行了定量萃取和分离，这3种水溶性卟啉的结构和物理化学性质是该萃取方法应用于其他溶质分离时的重要模型。以上结果对开发“多组分均相液-液萃取”新分离方法具有重要意义在不久的将来，新的多相分离现象的发现以及在含有有用溶质的大范围样品中的应用将得到积极的发展。少

New two types of three-phase separation phenomena were found by the charge neutralization of perfluorooctanate ion ; they are amine type in the neutral pH to alkaline solution and that of polar organic solvent in the acidic solution.In this study, the concentration and separation of several kinds of metal-chelate and physiological active substrates have been discussed in detail based on fundamental findings obtained from these phase separation phenomena.In the amine type (e.g.the case in the presence of n-amylamine), threephase separation phenomenon was confirmed in the pH range of 7 to 8.Each phases were successively water phase and two kinds of water-immisible phase (second phase and first phase) from upper side.The homogeneous liquid-liquid extraction method using these phenomena was applied to three components such as L-ascorbic acid, hemogrobin and alpha, beta, gamma, delta-tetrakis (4-trimethylaminophenyl) porphine (TTMAPP) assuming that separate the medical substances in human b … More lood.As the results, they were able to be separated into water (L-ascorbic acid), second (hemoglobin) and first (TTMAPP) phases, respectively using only a one-step process with addition of amylamine to the perfluorooctanoic acid solution.On the other hand, in the polar organic solvent type (e.g.the case in the presence of dimethylsulfoxide), the three-phase separation phenomenon was confirmed in the pH range of 0.42 to 0.46.This extraction method was applied to eight kinds of synthetic water-soluble porphyrin.As the results, three kinds of water-soluble porphyrin was quantitatively extracted and separated in water phase, second phase and first phase, respectively.The structure and physico-chemical property of these solutes is an important as a model when this extraction method is applied to the separation for other solutes.In conclusion, above-described valuable results for the development of new separation method "multi-compornents homogeneous liquid-liquid extraction"was obtained during the past two years.In the near future, the discovery of novel multi-phase separation phenomenon and the application to the extensive sample containing useful solute would be aggressively done. Less