THE EFFECTS OF LOW POWER LASER ON PAIN PROJECTION MECHANISMS

低功率激光对疼痛投射机制的影响

• 批准号: 05807141
• 负责人: SHIMOYAMA Naohito
• 金额: $ 0.9万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05807141/
• 关键词: LOW POWER LASER,; ARTIFICIAL MEMBRANE,; RED BLOOD CELL MEMBRANE,; POTASIUM CHANNEL,; SODIUM CHANNEL,; 相転移温; 膜の物性; 疼痛伝達機序; 膜物性

This project was constructed of 3 studies for clarifing the mechanism of analgesic effect. 1) the effect on hypotonic hemolysis of human red blood cell, 2) the effects on sodium and potasium channel, 3) the effects on DPPc membrane (artificial membrane),[result 1] The laser stabilized the membrane of damaged red blood cells and the deformability was activated by the laser irradiation.[result 2] We observed the potasium ions increseed, but the sodium ions were no changed by the laser irradiation.[result 3] Phase transition temperature was also unchanged by the laser irradiation.[conclusion] These results suggest that low-power He-Ne laser irradiation do not affect the physical characteristics fo artificial DPPC membranes. But the hypotonic hemolysis in human red cells were inhibited by the laser irradiation. This suggest that the laser has protective effects on red cell membranes from hypotonic hemolysis and stabilize the membranes.

本项目由3项研究组成，旨在阐明其镇痛作用的机制。1)对人红细胞低渗性溶血的影响；2)对钠离子和钾离子通道的影响；3)对DPPC膜(人工膜)的影响。[结果1]激光对受损红细胞膜起稳定作用，激活了膜的变形性。[结果2]激光照射后，钾离子增多，而钠离子无变化。[结果3]激光照射对DPPC膜的相变温度也没有影响。[结论]低功率He-Ne激光照射对DPPC膜的物理性质无明显影响。但激光照射可抑制人红细胞的低渗溶血作用。提示激光对红细胞膜具有抗低渗性溶血和稳定红细胞膜的作用。

项目成果

Kazuhiko Iijima,et al.: "Treatment of low power laser in pain relief from herpetic and post-herpetic neuralgia." Proceedings of 10th,Cong,Intern,Soc,for Laser Surg & Med.(Bangkok,Thailand). 98-98 (1993)

Kazuhiko Iijima 等人：“低功率激光治疗缓解带状疱疹和带状疱疹后神经痛的疼痛。”

Kazuhiko Iijima,et al.: "Irradiation of low power He-Ne laser on phosphalipid bilayers." Proceedings of 10th,Cong,Intern,Soc,for Laser Surg & Med.(Bangkok,Thailand). 163-163 (1993)

Kazuhiko Iijima 等人：“低功率氦氖激光照射磷脂双层。”

飯島一彦,下山直人,他: "疼痛外来における低出力レーザー療法" 骨・関節・靱帯. 7(6). 669-675 (1994)

Kazuhiko Iijima、Naoto Shimoyama 等人：“门诊疼痛诊所的低功率激光治疗”《骨骼、关节和韧带》7(6) (1994)。

下山直人: "低出力レーザー" エキスパートナース. 10(12). 92-97 (1994)

Naoto Shimoyama：“低功率激光”专家护士 10(12) 92-97 (1994)。

飯島一彦 ほか: "刺激による鎮痛法;低出力レーザー" ペインクリニック. 14. 29-34 (1993)

Kazuhiko Iijima 等人：“基于刺激的镇痛；低功率激光”Pain Clinic。14. 29-34 (1993)