A HISTOGENETICAL CLASSIFICATION OF OVARIAN TUMORS AND REMNANTS TUMORS --THE "MESONEPHRIC HYPOTHESIS"

基于有关人类性腺发生的新的组织发生学发现，提出了卵巢肿瘤的一个新的组织发生学分类(Satoh，1991a)。这种分类的概念如下。性腺内上皮细胞基本上起源于中肾，卵巢上皮性肿瘤来源于中肾起源的性腺内上皮细胞。从这一观点来看，参与卵巢上皮性肿瘤组织发生的组织被认为是性索和中肾系统，由专化性索(即颗粒细胞、支持细胞、卵泡性索、生精性索)、原始性索、中肾小球、透明细胞、中肾小管、中肾导管以及来自中肾导管尾部的部分膀胱和尿路组成。

A new histogenetical classification of ovarian tumors is presented, based upon new histogenetic findings concerning human gonadogenesis (Satoh, 1991a). The concept of this classification is as follows. The intragonadal epithelial cells are basically of mesonephric origin, and that ovarian epithelial tumors are derived from the intragonadal epithelial cells of mesonephric origin. From this viewpoint, the tissues involved in the histogenesis of ovarian epithelial tumors are considered to be the sex cords and the mesonephric system, consisting of specialized sex cords (i.e., granulosa cells, Sertoli cells, folliculogenous sex cords, seminiferous sex cords), primordial sex cords, mesonephric glomeruli, clear cells, mesonephric tubules, mesonephric ducts, and portions of the urinary bladder and urinary tract which are derived from the caudal portion of the mesonephric ducts.