A HISTOGENETICAL CLASSIFICATION OF OVARIAN TUMORS AND REMNANTS TUMORS --THE "MESONEPHRIC HYPOTHESIS"

卵巢肿瘤及残余肿瘤的组织遗传学分类--“中肾假说”

• 批准号: 05807153
• 负责人: SATOH Masahito
• 金额: $ 0.9万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05807153/
• 关键词: Mesonephros; Histogenetic classification; Ovarian tumors; Mesonephric remnants tumors; 原始性策腫瘍; 原始性策(Primordial sex cord); 卵巣細索(Folliculogenous sex cord); 原始性索腫瘍; 原始性索(Primordial sex cord); 卵胞細索(Folliculogenous sex cord)

A new histogenetical classification of ovarian tumors is presented, based upon new histogenetic findings concerning human gonadogenesis (Satoh, 1991a). The concept of this classification is as follows. The intragonadal epithelial cells are basically of mesonephric origin, and that ovarian epithelial tumors are derived from the intragonadal epithelial cells of mesonephric origin. From this viewpoint, the tissues involved in the histogenesis of ovarian epithelial tumors are considered to be the sex cords and the mesonephric system, consisting of specialized sex cords (i.e., granulosa cells, Sertoli cells, folliculogenous sex cords, seminiferous sex cords), primordial sex cords, mesonephric glomeruli, clear cells, mesonephric tubules, mesonephric ducts, and portions of the urinary bladder and urinary tract which are derived from the caudal portion of the mesonephric ducts.

基于人类性腺发生的新的组织遗传学发现，提出了卵巢肿瘤的一种新的组织遗传学分类（Satoh，1991 a）。这种分类的概念如下。性腺内上皮细胞基本上起源于中肾，卵巢上皮性肿瘤起源于中肾起源的性腺内上皮细胞。从这个观点来看，参与卵巢上皮性肿瘤组织发生的组织被认为是性索和中肾系统，由特化的性索组成（即，颗粒细胞、Sertoli细胞、卵泡生成性索、生精性索）、原始性索、中肾肾小球、透明细胞、中肾小管、中肾管以及源自中肾管尾部的膀胱和尿道部分。

项目成果

Satoh, Masahito: "Symposium II‐2: Histogenesis and Organogenesis of the Gonad in Human Embryos" Med. Electron Microsc. 27. 254-256 (1995)

Satoh，Masahito：“研讨会 II-2：人类胚胎性腺的组织发生和器官发生”Med. 27. 254-256 (1995)

Satoh,Masahito: "A histogenetical classification of ovarian tumors-The¨mesonephric hypothesis¨" 投稿中.

Satoh, Masahito：“卵巢肿瘤的组织遗传学分类 - 中肾假说”已提交。

Masahito Satoh: "Histogenesis and organogenesis of the gonad in human embryos" J.Anatomy. 177. 85-107 (1991)

Masahito Satoh：“人类胚胎性腺的组织发生和器官发生”J.Anatomy。

佐藤 正仁: "性腺の発生と機能の発現、発生分化の生理学、新生理化学体系、第7巻、分担" 医学書院, 313 (1991)

佐藤正仁：“性腺的发育和功能表达，发育和分化的生理学，新的生理化学系统，第 7 卷，分部” Igakushoin，313（1991）

Satoh,Masahito: "Symposium II-2: Histogenesis and Organogenesis of the Gonad in Human Embryos" Med.Electron Microsc.(1994)

Satoh, Masahito：“研讨会 II-2：人类胚胎性腺的组织发生和器官发生”Med.Electron Microsc.(1994)