DEVELOPMENT OF AN ELECTROCHEMICAL MEASUREMENT METHODS ABOUT BIOFUNCTIONAL MATERIALS AND THEIR APPLICATION TO NONAQUEOUS SOLUTION SYSTEMS
生物功能材料电化学测量方法的开发及其在非水溶液体系中的应用
基本信息
- 批准号:06640778
- 负责人:
- 金额:$ 1.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1994
- 资助国家:日本
- 起止时间:1994 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Studies for getting basic data concerning to redox and electron transfer about biofunctional materials and for developing sensors for use both in detection of those and in tracing their activities were carried out. Biofunctional materials, which are generally difficuit to exchange electrons between those and an electrode, were contained in fairly a thin film of hydrophilic polymer, polyacrylamide (PAA)coated on a platinum disk electrode. A cell was constructed with the electrode and an acentonitrile(AN) solution to investigate electrochemical functions. 1)A PAA and methylviologen were dissolved with water on a platinum disk and dried in a sil-ica gel descicator. From the cyclic voltammetry (CV) the cell constructed with the electrode was confirmed to share a necessary condition for carring out the research. 2)The platinum disk electrodes coated with a PAA membrane containing a heme protein (catalase, bleomycin, hemoglobin, or cytochrome c) were constructed. It was found from the electrode that CV behavior about the redox of oxygen were different each other according to a containing protain. It should be nescessary to investigate the effect against the fedox behavior of oxygen by the difference of protains and the charge of the iron. 3)The platinum disk electrodes coated with a PAA membrane con-taining some functional materials(NADH,NAD,PQQ,diaphrase)were constructed. It was found from the electrode that redox peak currents were proportional to the con-centration of the cyclohexanol in AN.4)The PAA in gel type used in the experiment as a matrix for fixing biofunctional materials close to platinum disk was investi-gated to elucidate electrochemical basic characteristics.(Pacifichem'95, part 1, ANYL 193(1995). (Honolulu, Dec 17-22))Informations about redox behavior of a cho-lesterol and an oxygen monoxide were also obtained by the platinum electrode coated with a PAA containing cobalt phthalocyanine or hemoglobine.
开展了关于生物功能材料氧化还原和电子转移的基本数据的研究,以及开发用于检测和跟踪其活性的传感器的研究。生物功能材料通常很难在这些材料和电极之间交换电子,它们被包含在一层相当薄的亲水性聚合物中,聚丙烯酰胺(PAA)涂在铂盘电极上。用该电极和丙烯腈(AN)溶液构建了电池,以研究其电化学功能。1)将PAA和甲基紫精在铂盘上用水溶解,并在Sili-ICA凝胶降解器中干燥。从循环伏安法(CV)证实,用该电极构建的电池具有开展研究的必要条件。2)在铂电极表面涂覆一层含有血红素蛋白(过氧化氢酶、博莱霉素、血红蛋白或细胞色素c)的PAA膜。从电极上发现,氧的氧化还原的循环伏安行为因所含蛋白质的不同而不同。因此,有必要研究不同浓度的铁和铁的电荷对氧的氧化还原行为的影响。3)在铂电极表面涂覆一层含有某些功能材料(NADH、NAD、PQQ、隔膜)的PAA膜。从电极上发现,氧化还原峰电流与环己醇的浓度成正比。4)以凝胶型PAA为基质,将生物功能材料固定在铂圆盘附近,以阐明其电化学基本特性(太平洋95,第1部分,ANYL 193(1995))。(火奴鲁鲁,12月17日至22日))通过在铂电极上涂覆含钴酞菁或血红素的PAA,还获得了有关胆甾醇和氧一氧化碳氧化还原行为的信息。
项目成果
期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.Izutu,T.Nakamura T.Arai,M.Ohmaki: "Some recent studies on the use of electrochemical sensors in nonaqueous solution chemistry" Electroanalysis. 7(9). 884-888 (1995)
K.Izutu、T.Nakamura T.Arai、M.Ohmaki:“关于在非水溶液化学中使用电化学传感器的一些最新研究”电分析。
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- 影响因子:0
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- 通讯作者:
T.Nakamura,C.Hayashi,T.Ogawara: "Potentiometric response properties of sensor membrane based on cobalt phtalocyanine conjugate-polymer in nonaqueous solutions" Bulletin of the chemical sciety of Japan. (印刷中).
T. Nakamura、C. Hayashi、T. Okawara:“非水溶液中基于钴酞菁共轭聚合物的传感器膜的电位响应特性”日本化学学会通报(正在出版)。
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T.Nakamura,H.Nishikawa: "Development of the method of an electrochemical measurement about biofunctional materials and its application to nonaqueous solution systems"
T.Nakamura、H.Nishikawa:“生物功能材料电化学测量方法的开发及其在非水溶液系统中的应用”
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
K.Izutsu,T.Nakamura,A.Arai,M.Ohmaki: "Some recent studies on the use of electrochemical sensors in nonaqueous solution chemistry" Electroanalysis. 7(9). 884-888 (1995)
K.Izutsu、T.Nakamura、A.Arai、M.Ohmaki:“关于在非水溶液化学中使用电化学传感器的一些最新研究”电分析。
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- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
中村俊夫,小川原鉄志 伊豆津公佑: "フタロシアニン金属錯体を化学結合した高分子を感応膜とする非水溶液用陰イオンセンサーの電位応答機構の研究" Rev.of Polarogr.40(3). 35- (1994)
Toshio Nakamura、Tetsushi Okawahara、Kosuke Izutsu:“非水溶液阴离子传感器的电位响应机制研究,其敏感膜是与酞菁金属络合物化学键合的聚合物”Rev. of Polarogr.40(3)。 - (1994)
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NAKAMURA Toshio其他文献
NAKAMURA Toshio的其他文献
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{{ truncateString('NAKAMURA Toshio', 18)}}的其他基金
A modification of preparation method of ancient iron artifacts for radiocarbon dating
古代铁器放射性碳测年制备方法的改进
- 批准号:
24652155 - 财政年份:2012
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Precise 14C dating of wooden cultural properties treated for preservation with PEG
用 PEG 进行保存的木质文化财产的精确 14C 测年
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22652072 - 财政年份:2010
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$ 1.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
A study on estimation of calendar age for wooden cultural properties with high precision by wiggle matching
摆动匹配高精度估算木质文物历法研究
- 批准号:
19300300 - 财政年份:2007
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A study of determining the tree-ring age with a precision of one year by 14C wiggle matching
14C摆动匹配一年精度测定树木年轮年龄的研究
- 批准号:
16320108 - 财政年份:2004
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$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Implication of intestinal lymphocytes in endotoxin-induced hepatic injury after partial hepatectomy in rats
肠淋巴细胞在大鼠肝部分切除术后内毒素性肝损伤中的意义
- 批准号:
15591396 - 财政年份:2003
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$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on accurate age determination of volcanic eruptions by high-precision 140 dating and a wiggle matching analysison charred wood from volcanic deposits
火山沉积物焦木高精度140测年及摆动匹配分析准确测定火山喷发年龄的研究
- 批准号:
13480020 - 财政年份:2001
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Kupffer cells modulate splenic, interleukin-10 production in endotoxin-induced liver injury after partial hepatectomy.
部分肝切除术后内毒素诱导的肝损伤中,库普弗细胞调节脾脏、白细胞介素 10 的产生。
- 批准号:
12671218 - 财政年份:2000
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Prevention of hepatic metastasis after surgery by angiogenesis inhibitor
血管生成抑制剂预防术后肝转移
- 批准号:
10671171 - 财政年份:1998
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$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on accurate age measurement of buried wood by high-precision 14C dating and 14C wiggle matching
高精度14C测年和14C摆动匹配准确测量埋藏木材年龄的研究
- 批准号:
10680174 - 财政年份:1998
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development and its application of anion sensor consist of polymer film for the use of nonaqueous solution
非水溶液用聚合物薄膜阴离子传感器的研制及其应用
- 批准号:
10640587 - 财政年份:1998
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)