Development of Selective Flow Reactions using Immobilized Organoaluminum Reagents Possessing Molecular Recognition Ability

本研究以具有分子识别能力的固定化有机铝试剂为研究对象，开展了以下几个方面的研究工作：1.开发可应用于流动合成的有机铝试剂选择性反应。(1)环氧化物顺序重排-Tishchenko反应的研究(1)环氧化物顺序重排-Tishchenko反应的研究以改性有机铝为催化剂，将γ-环氧醛转化为不饱和甲酸酯。具有分子识别能力的固定化有机铝试剂流动反应的研究(1)流动法烷基取代氧化锡的顺序重排-Tishchenko反应的研究烷基取代氧化苯乙烯的连续重排和Tishchenko二聚反应在室温下以较低的选择性对固定的、不溶于水的聚合物有机铝试剂得到了所需的酯。

This research project has been performed to develop selective flow reactions using immobilized organoaluminum reagents possessing molecular recognition ability as disclosed in the following points :1. Development of selective reactions capable of applying for flow synthetic application using organoaluminum reagents.(1) Study of sequential rearrangement-Tishchenko reaction of epoxidesModified organoaluminum reagent can be successfully utilized as an active catalyst for the consecutive rearrangement and Tishchenko dimerization of alkyl-substituted stirene oxides.(2) Study of Tishchenko reaction of various aldehydesThe combination of the modified organoaluminum reagent with a certain epoxides such as trans-stilbene oxide are suitable as effecting catalysts for the Tishchenko reaction of aromatic and aliphatic aldehydes.(3) Study of synthetic application of epoxyaldehydesbeta, gamma-epoxyaldehyde has been converted into unsaturated formates with the modified organoaluminum catalyst.2. Study of flow reaction using immobilized organoaluminum reagent possessing molecular recognition ability(1) Study of sequential rearrangement-Tishchenko reaction of alkyl-substituted stirene oxides in flow methodThe consecutive rearrangement and Tishchenko dimerization of alkyl-substituted stirene oxides has afforded the desired ester in low selectivity on stationary, insolubilized polymeric organoaluminum reagent at room temperature.