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Central peptidergic regulatory mechanims of sympatho-adrenomedullarly functions.

交感肾上腺髓质功能的中枢肽能调节机制。

基本信息

批准号：
06670115
负责人：
OSUMI Yoshitsugu
金额：
$ 1.28万
依托单位：
Kochi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670115/
关键词：
Sympathetic Nerve Adrenal Medulla Bombesin Prostaglandin Noradrenaline Adrenaline Interleukin-1beta

项目摘要

Central regulatory mechanisms of sympatho-adrenomedullaryl functions were examined in rats under urethane anesthesia. Results obtained are as follows : Intracerebroventricular (ICV) administration of bombesin elevated plasma levels of both noradrenaline (NA) and adrenaline (Ad), and nerve activities electrically recorded form both the sympathetic and adrenal branches of the splanchinic nerves. On the other hand, prostaglandin (PG) E2 by the same route selectively elevated the plasma level of NA alone, and nerve activity of the sympathetic but not the adrenal branch. 2) The effect of PGE2 to elevate the plasma level of NA was due to its activation of EP3 receptors in the brain. 3) Interleukin 1beta (IL-1beta), a madiator of immune signals, selectively elevated the plasma level of NA but not AD,as observed with PGE2.4) The effects of bombesin and IL-1beta on the plasma levels of NA and Ad were abolished by ICV pretreatment with indomethacin, an inhibitor of PG synthesis. 5) From the results with L-NAME,an inhibitor of nitric oxide (NO) synthetase, and exyhemoglobin, an NO scavenger, NO produced in the brain by IL-1beta probably mediates this cytokine-induced elevtion of plasma level of NA.From these results, it is suggested that two different types of neuronal cells probbly exist in the brain ; activation of one neuronal cell group ecxites both the sympathetic and adrenomedullarly systems, while activation of the other neuronal cell group selectively excites the sympathetic system alone. Receptors of bombesin are located on the former neuronal cell group, while those of IL-1beta are located on the latter neuronal cell group in the brain. PGs in the brain produced by bombesin and IL-1beta are probably involved in activation of these neuronal cell groups.

在乌拉坦麻醉下，研究了交感-肾上腺髓质功能的中枢调节机制。结果如下：侧脑室(Icv)注射蛙皮素可升高血浆去甲肾上腺素(NA)和肾上腺素(Ad)水平，电记录内脏神经的交感神经和肾上腺支的神经活动。另一方面，前列腺素(PG)E_2通过同样的途径选择性地单独升高血浆去甲肾上腺素(NA)水平，增加交感神经而不是肾上腺支的神经活动。2)PGE_2升高血浆NA水平的作用与其激活脑内EP3受体有关。3)免疫信号调节剂白介素1β(IL-1β)选择性地升高血浆NA水平，而不是AD水平，与PGE2.4相同。脑室注射PG合成抑制剂消炎痛，可阻断蛙皮素和IL-1β对血浆NA和AD水平的影响。5)从一氧化氮合酶抑制剂L-NAME和NO清除剂外周血色素的结果来看，IL-1β在脑内产生的NO可能介导了细胞因子引起的血浆NA值升高。由此推测，脑内可能存在两种不同类型的神经细胞，一种神经元细胞群的激活同时兴奋交感神经和肾上腺髓质系统，而另一种神经元细胞群的激活仅选择性地兴奋交感神经系统。蛙皮素的受体位于前一个神经细胞组，而IL-1β的受体位于脑内的后一个神经细胞组。蛙皮素和IL-1β在大脑中产生的PG可能参与了这些神经元细胞群的激活。