The experimental and clinical study on reducing radiation morbidity of upper gastraintestinal tract in the radiotherapy of extrahepatic bile duct cancer

取Koken公司生产的硅橡胶组织扩张器，放置于兔腹腔内。全麻下剖腹探查成功置入组织扩张器。未发现与组织扩张器放置有关的S并发症。兔子用腹部的扩张器做得很好。结论：腹膜腔内放置组织扩张器是安全可行的。我们还获得了CT扫描的固定装置，确定了检查细节。在临床应用中，将扩张器放置于盆腔恶性肿瘤术后及放疗后复发患者的腹膜腔内。在放置扩张器后，对该患者进行三维CT治疗计划。用这种方法，我们可以减少小肠和大肠扁桃体剂量的十分之一，没有这种方法。这些结果发表在以下论文中：第16届国际癌症大会论文集、日本放射学会第30届秋季年会论文集以及1996年第34卷《国际放射肿瘤学生物学物理杂志》

Silastic tissue expanders (made by KOKEN company) were obtained and placed in the rabbit abdominal cavity. The Placement of tissue expander was carried out by lapparotomy under the general anesthesia successfully. Complication s related to the placement of tissue expander was not observed. The rabbit was doing well with the expander in the abdomen. We concluded that the intraperitoneal placement of the tissue expander was feasible and safe. We also obtained the immobilization device for CT scan and fixed the examination details. In the clinical application, the expander was placed in the abdominal cavity of the patient with post operative and post raediotherapy recurrent in trapelvic malignant tumor. After the placement of the expander, three dimensional CT treatment planning was performed on this patient. With this method, we could reduce the dose of small and large intestine almonst 1/10th of the dose wdithout this method. These results were reported at the following papers, the proceedings of the 16th international cancer congress, the proceedings of the 30th annual autumn meeting of the Japan Radiological Society, and International Journal of Radiation Oncology Biology Physics volume 34,1996