The experimental and clinical study on reducing radiation morbidity of upper gastraintestinal tract in the radiotherapy of extrahepatic bile duct cancer

肝外胆管癌放疗中降低上消化道辐射发病率的实验与临床研究

• 批准号: 06670893
• 负责人: MIYASAKA Kazuo
• 金额: $ 1.34万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670893/
• 关键词: Tissue expander; 3 dimensional photon treatment planning; Gastrointestinal tract; Morbidity; CT; Extrahepatic bile duct cancer; Tissue Expander; 胆管癌; ティシュー・エクスパンダー

Silastic tissue expanders (made by KOKEN company) were obtained and placed in the rabbit abdominal cavity. The Placement of tissue expander was carried out by lapparotomy under the general anesthesia successfully. Complication s related to the placement of tissue expander was not observed. The rabbit was doing well with the expander in the abdomen. We concluded that the intraperitoneal placement of the tissue expander was feasible and safe. We also obtained the immobilization device for CT scan and fixed the examination details. In the clinical application, the expander was placed in the abdominal cavity of the patient with post operative and post raediotherapy recurrent in trapelvic malignant tumor. After the placement of the expander, three dimensional CT treatment planning was performed on this patient. With this method, we could reduce the dose of small and large intestine almonst 1/10th of the dose wdithout this method. These results were reported at the following papers, the proceedings of the 16th international cancer congress, the proceedings of the 30th annual autumn meeting of the Japan Radiological Society, and International Journal of Radiation Oncology Biology Physics volume 34,1996

获得硅橡胶组织扩张器（KOKEN公司生产）并置于兔腹腔中。在全身麻醉下，成功地进行了组织扩张器的放置。未观察到与组织扩张器放置相关的并发症。兔子在腹部扩张器的情况下表现良好。我们的结论是，腹膜内放置的组织扩张器是可行的和安全的。我们还获得了用于CT扫描的固定装置，并固定了检查细节。在临床应用中，将扩张器放置于盆腔恶性肿瘤术后或放疗后复发患者的腹腔内。在置入扩张器后，对该患者进行三维CT治疗计划。用此法可使小肠和大肠的剂量减少约1/10。这些结果在下列论文中报道，第16届国际癌症大会会议录，日本放射学会第30届秋季年会会议录，和国际放射肿瘤生物学物理学杂志第34卷，1996

项目成果

T.Kamada, et al.: "Radiotherapy dedicated CT system-RT-CT system-the Hokkaido University experience." Proceedings of the 16th international cancer congress. 2713-2717 (1994)

T.Kamada等：“放射治疗专用CT系统-RT-CT系统-北海道大学的经验”。

T.Kamada, et al.: "The role of radiotherapy in the management of extrahepatic bile dudt cancer : An analysis of 145 consecutive patients treated with intraluminal and/or external beam radiotherapy" Int. J.Radiation Oncology Biol. Phys. 34. (1996)

T.Kamada 等人：“放射治疗在肝外胆汁癌治疗中的作用：对 145 名连续接受腔内和/或外束放射治疗的患者进行的分析”Int。

T.Nakakoshi.et.al.: "Magnetic resonance imaging of Long-Evans Cinnamon Rets as a new modol of hepatocelular carcinoma." Acad.Radiol.2. 50-52 (1995)

T.Nakakoshi.et.al.：“Long-Evans Cinnamon Rets 的磁共振成像作为肝细胞癌的新模型。”

T. Kamada, et al.: "Radiotherapy dedicated CT system-RT-CT system-the Hokkaido University experience." Proceedings of the 16th international cancer congress.2713-2717 (1994)

T. Kamada等：“放射治疗专用CT系统-RT-CT系统-北海道大学的经验”。

T. Nakakoshi, et al.: "Magnetic resonace imaging long-evans cinnamon rats as a new model of hepatocellular carcinoma" Acad Radiol. 2. 50-52 (1995)

T. Nakakoshi 等人：“长埃文斯肉桂大鼠的磁共振成像作为肝细胞癌的新模型”Acad Radiol。