A development of new radiopharmaceuticals for respiratory diseases

本研究的目的是利用Technegas发生器从^<99m>Tc-technegas中生成不同的示踪剂。在97%的Ar和3%的氧气存在下，在发生器中形成了p气体。磷酸盐缓冲盐水（PBS）中p -气的易提取性，大鼠静脉注射p -气后的分布及放射色谱分析结果表明p -气具有高技术酸盐（TcO_4^-）的性质。^<99m>同样条件下，techgas发生器也产生了Tc-DTPA气体（D-gas）。d -气体在体外实验中表现出与p -气体相同的物理化学特性。在体内研究中，吸入p气体的半衰期（T_<1/2>）与吸入TcO_4^-气溶胶的半衰期无显著差异。p -气体的T_<1/2>比DTPA气溶胶的T_<1/2>要快得多。吸烟者p -gas T_<1/2>比非吸烟者p -gas T_<1/2>更快（p<0.01）。D-gas的T_<1/2>在正常非吸烟者中为19.8<正负>4.0 min，在吸烟者中为12.0<正负>2.8 min，在特发性间质性肺炎（IIP）中为31<正负>11.2 min，需要进一步研究这些示踪剂在肺部疾病中的清除率以评估其临床应用价值。

The aim of this study is to generate different tracers from ^<99m>Tc-technegas by using Technegas generator.Pertechnegas (P-gas) was formed in the generator in the presence of 97% Ar and 3% oxygen.The easy extractability of P-gas in the phosphate buffered saline (PBS), the distribution seen in rats after intravenous injection of P-gas and the results of the radiochromatography showed that P-gas behaved like pertechnetate (TcO_4^-).^<99m>Tc-DTPA gas (D-gas) was also generated in the same condition by technegas generator. D-gas showed same physicochemical sharacteristics to P-gas in vitro experiment.In vivo study, the clearance half time (T_<1/2>) of inhaled P-gas has shown no significant difference to that of TcO_4^- aerosol.T_<1/2> of P-gas was considerably faster in comparison with T_<1/2> of DTPA aerosol. However, T_<1/2> of P-gas was more rapid in smokers compared with T_<1/2> in nonsmokers (p<0.01).T_<1/2> of D-gas was 19.8<plus-minus>4.0 min in normal non-smoker subjects, 12.0<plus-minus>2.8 min in smoker subjects, and 31<plus-minus>11.2 min in idiopathic interstitial pneumonia (IIP)Further study of the clearance of these tracers in pulmonary diseases is required to assess clinical usefulness.