A Basic Study of Microwave Dynamic Therapy for Postoperative Residual Gastric Cancer

在日本白色兔VX_2肿瘤模型上，用w/o/w型聚血卟啉醚/酯（PHE）乳剂进行微波照射的抗肿瘤作用的初步研究，局部注射w/o/w型PHE乳剂（含PHE 0.5mg/kg）后6 h，瘤内PHE浓度为10.4 ~ <plus-minus>2.4 μ g/g，与静脉注射PHE（2 mg/kg）后的浓度相当。局部注射w/o/w型PHE乳剂后，PHE血药浓度在可测范围内。局部注射w/o/w型PHE乳剂和静脉注射PHE后，微波照射对肿瘤的缩小率分别为89.8 <plus-minus>± 12.1%和77.4 <plus-minus>± 20.7%，无微波本身的热效应。结论：PHE乳剂局部注射是一种有效的给药途径，PHE乳剂局部注射后微波照射有可能成为治疗浅表恶性肿瘤的新方法。

In VX2 tumor model of Japanese white rabitts, fundamental investigation on the antitumor effects of microwave irradiation with w/o/w poly-hematoporphyrin ether/ester (PHE) emulsion were carried out.The intratumoral concentration of PHE at 6 hours after local injection of w/o/w PHE emulsion (in volving PHE 0.5mg/kg) was 10.4<plus-minus>2.4mug/g, and it was almost equal to the concentration after intravenous administration of PHE (2mg/kg). On the other hand, serum concentration of PHE after local injection of w/o/w PHE emulsion was under limit of measuremenThe reduction ratio of the tumor by microwave irradiation after administration of PHE was observed 89.8<plus-minus>12.1% in local injection of w/o/w PHE emulsion and 77.4<plus-minus>20.7% in intravenous administration of PHE,respectively without hyperthermic effect caused by microwave itself. Antitumor effect was not recognized in microwave irradiation alIn conclusion, local injection of w/o/w PHE emulsion may be beneficial as an administration route of PHE and microwave irradiation after PHE administration has possibility for a new treatment of superficial malignant tumors.