The role of humoral factors in the gastric hyperdynamic circulation of chronic portal hypertension

在四氯化碳(CCl_4)诱导的大鼠胃高动力循环中，观察了胰高血糖素的作用。通过静脉输注胰升糖素抗血清，选择性地将胰升糖素从循环中消除。用激光多普勒血流仪测定胃血流量。胰高血糖素抗血清对对照组大鼠胃血流量无影响，而在肝硬变门脉高压大鼠，高血糖素抗血清显著减少胃血流量(30%)。胰升糖素抗血清不能完全排除肝硬变大鼠胃高动力状态。由此可见，胰高血糖素参与了与肝硬变门脉高压相关的胃高动力循环的一部分。

The role of glucagon as a mediator of gastric hyperdynamic circulation, induced by carbon tetrachloride (CCl_4), was assessed in cirrhotic rats. A selective elimination of pancreatic glucagon from the circulation was achieved by the intravenous infusion of a glucagon antiserum. Gastric blood flow was measured by laser-Doppler flowmetry. The glucagon antiserum had no effect on the blood flow in the stomach in control rats, while in cirrhotic portal hypertensive rats, the glucagon antiserum significantly reduced gastric blood flow (30%). The glucagon antiserum did not completely exclude the gastric hyperdynamic state in the cirrhotic rats. It would thus appear that glucagon contributes to a portion of the gastric hyperdynamic circulation associated with cirrhotic portal hypertension.