The Study in the Effect of Oriental Medicines on Sexual Function and Testis Function -Especially about Jashoshi-

目前，还没有一种药物对勃起功能障碍有效。我们一直在努力开发新的技术药物，这是有效的勃起功能障碍。Jashoshi是东方药物之一，据说自古以来对勃起功能障碍有效。我们对它的药用作用进行了研究，得到以下结果。在正常小鼠和实验性隐睾小鼠中口服Jashoshi引起以下情况。1.增加了挂载次数，缩短了挂载潜伏期。2.血清睾酮浓度有升高的趋势。3.胰蛋白酶样蛋白酶活性的颌下腺，这是雄激素在小鼠中的靶器官之一，增加。电泳中的酶谱分析与睾酮给药中的相同。4.颌下腺表皮生长因子mRNA表达增强，与睾酮组相同。然而，在去势小鼠中，Jashoshi给药没有变化，并且在所有小鼠组中，血清LH和FSH浓度不受Jashoshi给药的影响。这些结果表明，Jahshoshi提高小鼠的性行为和血清睾酮浓度。另一个大概是其中一个的机制。血清LH和FSH浓度无变化，表明Jashoshi对睾丸有直接作用。

At present, there is no medicine which is effective in erectile dysfunction. We have been trying to develope with new techniques medicines which are effective in erectile dysfunction. Jashoshi is one of the oriental medicines which have been said to be effective in erectile dysfunction from ancient times. We have investigated its medicinal action, and obtained following results. Oral administration of Jashoshi in normal and experimentally cryptorchid mice caused the following things. 1. The number of times of mount was increased and the mount latency was shortened. 2. The tendency was toward higher serum testosterone concentrations. 3. Trypsin-like protease activity of the submaxillary gland, which is one of the target organs of androgen in mice, was increased. Zymogramatic analysis in electrophoresis was the same as in testosterone administration. 4. M-RNA expression of epidermal growth factor in the submaxillary gland was enhaned, which was the same as in testosterone administration. However, there were no changes in castrated mice by Jashoshi administration, and in all groups of mice, seurm LH and FSH concentrations were not affected by Jashoshi administration. These results indicate that Jahshoshi increases mice sexual behavior and serum testosterone concentration. And presumably the other is the mechanism involved of one. No changes in serum LH and FSH concentrations suggest that Jashoshi has direct actions on testes.