Efficacy of new mono-methacrylate esters as a dentin primer

新型单甲基丙烯酸酯作为牙本质底漆的功效

• 批准号: 06671925
• 负责人: HASEGAWA Tokuji
• 金额: $ 1.34万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671925/
• 关键词: Dentin Bonding; Dentin Primer; Esterified Methacrylate; xylitol; Contraction Gap; Tensile Bond Strength; デンティンプライマー; メタクリル酸エステル; NMR(磁気共鳴スペクトル)

Some esterified methacrylate with polyvalent alcohol such as glyceryl methacrylate and erythritol methacrylate, have been developed and reported as effective dentin primers. The purpose of this study was to synthesize a new esterified methacrylate monomer, xylitol mono-methacrylate (2, 3, 4, 5-tetrahydroxypentyl methacrylate : XM) to avoid the possible side effect on the skin tissue, and to determine the bonding efficacy of the aqueous solution of this monomer.XM was synthesized by acylation of xylitol with methacryloyl chloride. Powdered xylitol, 4-dimethylaminopyridine (DMAP) and hydroquinone were completely dissolved into pyridine. Freshly distillled methacryloyl chloride was then dropped into the solution under dry argon atmosphere. The XM in the mixture was spread out as a single spot (Rf=0.30) on a TLC plate with the chloroform-ethanol elution [70 : 30]. The dropwise method yields 24.2%. The chemical structure of XM was determined by lnfrared (1R) analysis.The experimental dentin … More primers were prepared as aqueous solutions of the XM at the concentration of 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 and 55%. The bonding efficacy of the primers was evaluated by measuring the polymerization contraction gap in a cylindrical dentin cavity and tensile bond strength to flat dentin surface. The cavity walls as well as the flat dentin surface were cleaned with EDTA, primed with the primer and applied the bonding agent (Clearfil Photo Bond) before cavity filling and application of resin composite on the flat dentin. Marginal gaps between the dentin cavity and the resin composite could not observe with the 30 to 50% XM solution. The tensile bond strengths of the primers were 16.5<plus-minus>4.6 MPa [5%], 12.71<plus-minus>3.4 MPa [15%], 14.9<plus-minus>4.6 MPa [25%], 16.8<plus-minus>5.8 MPa [35%], 20.9<plus-minus>4.1 MPa [45%] and 21.6<plus-minus>5.The aqueous solution of new synthesized monomer (XM) was effective as a dentin primer at the concentration of 30 to 50%. Before clinical more researching effort to the possible side effect on the skin tissue is required. Less

一些用多元醇酯化的甲基丙烯酸酯，例如甲基丙烯酸甘油酯和甲基丙烯酸赤藓糖醇，已被开发并报道为有效的牙本质底漆。本研究的目的是合成一种新的酯化甲基丙烯酸酯单体，木糖醇单甲基丙烯酸酯（2,3,4,5-甲基丙烯酸四羟基戊酯：XM），以避免对皮肤组织可能产生的副作用，并确定该单体水溶液的粘合功效。XM是通过木糖醇酰化合成的 甲基丙烯酰氯。将粉末状木糖醇、4-二甲氨基吡啶(DMAP)和氢醌完全溶解在吡啶中。然后在干燥的氩气氛下将新蒸馏的甲基丙烯酰氯滴入该溶液中。混合物中的 XM 在 TLC 板上展开为单个点（Rf=0.30），用氯仿-乙醇洗脱 [70:30]。滴加法产率为24.2%。通过红外 (1R) 分析确定 XM 的化学结构。实验牙本质底漆制备成浓度为 5、10、15、20、25、30、35、40、45、50 和 55% 的 XM 水溶液。通过测量圆柱形牙本质腔中的聚合收缩间隙和与平坦牙本质表面的拉伸粘合强度来评估底漆的粘合效果。用 EDTA 清洁空腔壁以及平坦的牙本质表面，用底漆涂底漆并涂上粘合剂 (Clearfil Photo Bond)，然后进行空腔填充并在平坦的牙本质上应用树脂复合材料。使用 30% 至 50% XM 溶液无法观察到牙本质腔和树脂复合材料之间的边缘间隙。底漆的拉伸粘结强度分别为16.5±4.6 MPa [5%]、12.71±3.4 MPa [15%]、14.9±4.6 MPa [25%]、16.8±5.8 MPa [35%]、20.9±4.1 MPa [45%] 和 21.6±5.新合成单体(XM)的水溶液在30至50％的浓度下作为牙本质底漆是有效的。在临床之前，需要对皮肤组织可能产生的副作用进行更多研究。较少的