Genetic polymorphism of drug metabolizing enzymes in oral cancer patients and its relationship to susceptibility to carcinogenesis of oral cavity.

口腔癌患者药物代谢酶基因多态性及其与口腔癌易感性的关系

• 批准号: 06672006
• 负责人: ICHIKAWA Takeshi
• 金额: $ 1.34万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06672006/
• 关键词: Oral Cancer; Susceptibity to Carcinogens; Genetic Polymorphism

Genetic polymorphisms of CYPIA1 and GST1, which may play important roles in metabolic activation or detoxification of polycyclic aromatic hydrocarbons such as benzo (a) pyrene, were examined in the patients with oral squamous cell carcinomas (SCC).1.The frequency of genotypes, Ile/Ile, Ile/Val and Val/Val, were 0.60,0.33 and 0.07, respectively in the patients with oral SCC.Comparing with non oral cancer patients or healthy Japanese population, the number of rare homozygote (Val/Val) genotype was relatively higher than those of controls.2.Comparing the incidence of the presence of at least one GST1 gene (GST(+)) or its complete deletion (GST(-)) between oral cancer patients and controls, there was no significant difference observed (43.3% versus 46.6%).3.When the total amounts of cigarette consumption dose were estimated among patients with different CYPIA1 genotypes, the mean value of Val/Val genotype was less than those of another genotypes.4.Val/Val homozygotes, which is considered to be a high risk group against lung cancer induced by cigarette smoking, was found in 13.7% of the patients with SCC of lower gingiva and the dose of cigarette consumption in those patients were much less than those of another genotypes.In conclusion, Val/Val homozygote may be also susceptible for smoking conducted lower gingival carcinoma and it is suggested that the mechanisms of carcinogenesis are not same in the each site of the oral cavity.

本研究对口腔鳞状细胞癌(SCC)患者进行了CYPIA1和GST1基因多态性的检测。1.口腔鳞癌患者Ile/Ile、Ile/Val和Val/Val基因频率分别为0.60、0.33和0.07，与非口腔癌患者和健康日本人比较，差异有统计学意义。2.口腔癌患者中至少存在一个GST1基因(GST(+))或其完全缺失(GST(-))的发生率与对照组比较，差异无统计学意义(43.3%对46.6%)。3.估计不同CYPIA1基因携带者的香烟总消费剂量时，Val/Val基因的平均值低于其他基因的平均值。结论：Val/Val纯合子也可能是吸烟导致低位牙龈癌的易感基因，提示口腔各部位的致癌机制不尽相同。