Membrane filtration of macromolecular substances: Measurement and Modelling on the micro- and macro-scales

对有关过滤过程中的结构和流动的空间和时间分辨MRI数据(MRI：磁共振成像)进行建模将有助于深入了解中空纤维膜中大分子的过滤过程。完整的工艺参数也在微观上决定过滤过程--除了微观上的，空间变化的参数，如膜特性和要过滤的物质。该提案集中于合适的测量方案和过滤模型，以探索沉积物的物理化学性质、分散系数、混合和可逆性。在中空纤维膜过滤过程中，将测量大分子溶液的结构图像和流动。速度场将与沉积物及其几何形状以及可能在空间上变化的粘度相关联。色散系数将在空间分辨率上进行测量。在过滤过程中对这些数量进行系统的现场测量将与宏观数量的测量相结合。这将为过滤模型的进一步发展奠定基础。重点将是结合微观和宏观参数，在不同长度尺度上模拟过滤过程。

Modelling of spatially and time resolved MRI data (MRI: magnetic resonance imaging) regarding structure and flow during filtration will lead to an in-depth understanding of filtration processes of macromolecules in hollow fiber membranes. Integral process parameters determine the filtration processes also on the microscopic scale – in addition to microscopically, spatially varying parameters like membrane properties and substances to be filtrated. The proposal focuses on questions of appropriate measurement protocols and on filtration modelling exploring the physicochemical properties of deposits, the dispersion coefficients, mixing and reversibility.Structural images and flow of macromolecular solutions will be measured during filtration in hollow fiber membranes. Velocity fields will be correlated with the deposits and their geometry as well as with a potentially spatially varying viscosity. Dispersion coefficients will be measured spatially resolved. A systematic in situ measurement of these quantities during filtration will be combined with the measurement of macroscopic quantities. This will be the basis for further development on filtration models. The focus will be to combine microscopic and macroscopic parameters for modelling the filtration processes on different length scales.