The role of the neuronal Hu proteins in the regulation of the BMP signalling pathway

神经元Hu蛋白在BMP信号通路调节中的作用

• 批准号: DP0559550
• 负责人: Dr Kirk Jensen
• 金额: $ 21.38万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559550
• 关键词: role; neuronal; Hu; proteins; regulation

We aim to understand the critical decision of a neural progenitor to commit to becoming a neuron. The BMP signalling pathway is central in this decision. Neural progenitors appear to become insensitive to BMP signals, and this lack of signalling leads to neuronal differentiation. We hypothesise that neuronal identity is regulated by an unusual genetic switch- the translational regulation by the neuronal Hu proteins of two proteins in the BMP pathway. Verification of a post-transcriptional regulatory mechanism for cell fate determination would be a major discovery, and may prompt investigation of how to harness the neuron-inducing function of the Hu proteins to address the therapeutic need for new neurons in neurologic diseases.

我们的目标是了解神经祖细胞致力于成为神经元的关键决定。 BMP 信号通路是这一决定的核心。 神经祖细胞似乎对 BMP 信号变得不敏感，这种信号传导的缺乏导致神经元分化。 我们假设神经元身份是由一种不寻常的基因开关调节的，即 BMP 通路中两种蛋白质的神经元 Hu 蛋白的翻译调节。 验证细胞命运决定的转录后调节机制将是一项重大发现，并可能促使研究如何利用 Hu 蛋白的神经元诱导功能来满足神经系统疾病中新神经元的治疗需求。