Effect of Bcl-2 proteins on mitochondrial structure, dynamics and function (A09*)

Bcl2家族蛋白是线粒体细胞凋亡途径的重要调节因子。除了这一功能，证据表明，Bcl-2蛋白在几个线粒体过程中还有额外的功能，这些功能以及涉及的分子机制仍然知之甚少。这项建议的主要目的是剖析在线粒体组织和功能中的不同作用，并揭示潜在的分子机制。

The proteins of the Bcl-2 family are critical regulators of the mitochondrial pathway of apoptosis. Besides this function, evidence suggests that the Bcl-2 proteins have additional functions on several mitochondrial processes which, together with the molecular mechanisms involved, remain poorly understood. The main goal of this proposal is to dissect the differential role of the Bcl-2 proteins in mitochondrial organization and function and to uncover the underlying molecular mechanisms.