Effect of Bcl-2 proteins on mitochondrial structure, dynamics and function (A09*)

Bcl-2 蛋白对线粒体结构、动力学和功能的影响 (A09*)

• 批准号: 445726542
• 金额: --
• 依托单位: Arbeitsgruppe Membrane Biophysics
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/445726542?language=en
• 关键词: Effect; Bcl; proteins; mitochondrial; structure

The proteins of the Bcl-2 family are critical regulators of the mitochondrial pathway of apoptosis. Besides this function, evidence suggests that the Bcl-2 proteins have additional functions on several mitochondrial processes which, together with the molecular mechanisms involved, remain poorly understood. The main goal of this proposal is to dissect the differential role of the Bcl-2 proteins in mitochondrial organization and function and to uncover the underlying molecular mechanisms.

Bcl-2家族的蛋白质是细胞凋亡的线粒体途径的关键调节剂。除此功能外，有证据表明Bcl-2蛋白在几个线粒体过程中具有额外的功能，这些功能以及所涉及的分子机制仍然知之甚少。该提案的主要目标是剖析Bcl-2蛋白在线粒体组织和功能中的不同作用，并揭示潜在的分子机制。