Effect of Bcl-2 proteins on mitochondrial structure, dynamics and function (A09*)

点击翻译按钮获取中文摘要

The proteins of the Bcl-2 family are critical regulators of the mitochondrial pathway of apoptosis. Besides this function, evidence suggests that the Bcl-2 proteins have additional functions on several mitochondrial processes which, together with the molecular mechanisms involved, remain poorly understood. The main goal of this proposal is to dissect the differential role of the Bcl-2 proteins in mitochondrial organization and function and to uncover the underlying molecular mechanisms.