Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake (P02)

TH 对单细胞功能的影响以及与肝脏中枢调节和激素摄取的相关性 (P02)

• 批准号: 445852444
• 金额: --
• 依托单位: Institut für experimentelle und klinische Pharmakologie und Toxikologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/445852444?language=en
• 关键词: Impact; TH; tanycyte; functions; relevance

Tanycytes are important gatekeepers to transport TH into the CNS. Tanycytes themselves react to TH, which could modulate essential functions of tanycytes, such as their morphology or the transport of hormones. This project will focus on the role of TH in tanycytic functions and will clarify their effects on tanycytic morphology and hormonal transport into the cerebrospinal fluid. Additionally, this project will clarify the importance of local tanycytic distribution of TH into the VMH, which has an influence on liver metabolism.

伸展细胞是TH向中枢转运的重要守门细胞。伸展细胞本身对TH有反应，TH可以调节伸展细胞的基本功能，如形态或激素的转运。本项目将集中于TH在tanycytic功能中的作用，并将阐明其对tanycytic形态和激素转运到脑脊液中的影响。此外，本项目将阐明TH在VMH中的局部延伸分布的重要性，这对肝脏代谢有影响。