Strategies to increase local T3 availability in liver (P16)
Strategies to increase local T3 availability in liver (P16)
增加肝脏局部 T3 可用性的策略 (P16)
批准号：
445865563
负责人：
金额：
$0.0万
依托单位国家：
德国
项目类别：
CRC/Transregios
财政年份：
2020
资助国家：
德国
项目状态：
已结题
起止时间：
2019-12-31 至 2023-12-31
中文摘要
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英文摘要
T3 is a key regulator of hepatic lipid metabolism. Hypothyroidism has been linked to non-alcoholic (obesity-/ diabetes-associated) hepatosteatosis and its sequelae. We aim to elevate local T3 concentrations by steering activities of T3-degrading deiodinase isozymes in hepatocytes by using selective deiodinase (DIO) isozyme inhibitors. Local T3 effects will be monitored by T3-sensitive reporter constructs expressed in THAI mouse-derived primary hepatocyte cultures and hiPSC-derived hepatocyte cell lines.
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