The role of cyclic nucleotides in the regulation of adipose tissue resident myeloid cells (P17)

环核苷酸在调节脂肪组织驻留髓样细胞中的作用（P17）

• 批准号: 448272911
• 金额: --
• 依托单位: Institut für Pharmakologie und Toxikologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/448272911?language=en
• 关键词: role; cyclic; nucleotides; regulation; adipose

This project aims to investigate the role of cyclic GMP (cGMP) signalling in myeloid cells during metaflammation. Although myeloid cells play an outstanding role in adipose tissue (AT) inflammation, not much is known about the signalling pathways involved. Our previous work shows that cGMP signaling is negatively affected in adipose tissue during obesity. In this project, we will identify the cGMP signalling components in AT-resident macrophages and the effect of cGMP on macrophage function during metaflammation. Furthermore, we will analyse cGMP signalling in vivo and in human macrophages during obesity and metaflammation.

本项目旨在研究循环GMP （cGMP）信号在骨髓细胞炎症过程中的作用。尽管髓细胞在脂肪组织（AT）炎症中起着突出的作用，但对所涉及的信号通路知之甚少。我们之前的工作表明，肥胖期间脂肪组织中的cGMP信号受到负面影响。在本项目中，我们将确定at巨噬细胞中的cGMP信号成分，以及cGMP对巨噬细胞在炎症过程中的功能的影响。此外，我们将分析体内和人类巨噬细胞在肥胖和炎症期间的cGMP信号。