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Roles of multifunctional adaptor proteins, GGAs, in membrane traffic

Roles of multifunctional adaptor proteins, GGAs, in membrane traffic
多功能衔接蛋白 GGA 在膜运输中的作用
批准号:
15209002
负责人:
NAKAYAMA Kazuhisa
金额:
$32.28万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2003
资助国家:
日本
项目状态:
已结题
起止时间:
2003 至 2005

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中文摘要
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英文摘要
In this research project, we revealed the followings on GGAs and its related Tom1 family proteins.(1)We found that ARFs bind to the N-GAT subdomain of the GAT domain of GGAs.(2)By X-ray crystallography, we revealed the three-dimensional structure of the GGA3-GAT domain in complex with ARF.(3)We found that ubiquitin bind to the C-GAT subdomain of the GAT domain of GGAs and Tom1 family proteins.(4)By X-ray crystallography, we revealed the three-dimensional structure of the GGA3-GAT domain and that of the Tom1-GAT domain in complex with ubiquitin.(5)We found that Tollip (Toll-interacting protein) interacts with the GAT domain of the Tom1 family proteins.(6)We revealed that Tollip recruits Tom1 family proteins and ubiquitinated proteins onto endosomes.
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会议论文
Shakoori, A. et al.: "Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER"Biochem.Biophys.Res.Commun.. 312. 850-857 (2003)
Shakoori, A. 等人:“定位于高尔基体和内质网的五次跨膜蛋白家族的鉴定”Biochem.Biophys.Res.Commun.. 312. 850-857 (2003)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1074/jbc.m502442200
发表时间: 2005-06-17
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Yoshimura, S, Yoshioka, K, Nakamura, N]
通讯作者: Nakamura, N
Structure determination of GGA-GAE and gl-ear in complex with peptides : crystallization of low-affinity complexes in membrane traffic.
肽复合物中 GGA-GAE 和 gl-ear 的结构测定:膜运输中低亲和力复合物的结晶。
DOI: --
发表时间: 2005
期刊: Acta.Cryst.D. 61
影响因子: --
作者: [Yamada, Y., Inoue, M., Shiba, T., Kawasaki, M., Kato, R., Nakayama, K., Wakatsuki, S.]
通讯作者: S.
Roles of ARFRP1 (ADP-ribosylation factor-related protein1)in post-Golgi membarane trafficking.
ARFRP1(ADP-核糖基化因子相关蛋白1)在高尔基体膜后运输中的作用。
DOI: --
发表时间: 2005
期刊: J. Cell Sci. 118
影响因子: --
作者: [Shin, H.-W.et al.]
通讯作者: H.-W.et al.
25
    Coupling of membrane traffic and cytoskeleton remodeling in the regulation of cell motility
    • 批准号:
      22390013
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2010
    • 负责人:
      NAKAYAMA Kazuhisa
    • 依托单位:
    Regulation of membrane traffic and ubiquitination by small GTPases
    • 批准号:
      18209003
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.2万
    • 财政年份:
      2006
    • 负责人:
      NAKAYAMA Kazuhisa
    • 依托单位:
    Roles of clathrin-adaptor-like proteins in intracellular protein traffic.
    ROLES OF GTP-BINDING PROTEINS IN THE FORMATION OF INTRACELLULAR TRANSPORT VESICLES
    • 批准号:
      09480148
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $8.06万
    • 财政年份:
      1997
    • 负责人:
      NAKAYAMA Kazuhisa
    • 依托单位:
    海外基金